{
  "abstract": "Nitric oxide (NO) plays crucial regulatory roles in accelerating cutaneous wound repair via modulating angiogenesis and macrophage polarization. Herein, a reactive oxygen species (ROS)-responsive GelMA/L-arginine (L-Arg) composite hydrogel was fabricated through 405-nm photocrosslinking for localized NO delivery and high-efficiency wound treatment. Physicochemical characterizations verified that L-Arg incorporation maintained the favorable moldability and interconnected porous microstructure of pristine GelMA hydrogel, and enabled sustained ROS-triggered NO release under oxidative microenvironment. In vivo full-thickness skin defect rat models demonstrated that the GelMA/L-Arg hydrogel markedly expedited wound closure, achieving a healing rate of 93.7% at day 14, and facilitated ordered re-epithelialization with a collagen area fraction of 64.6%. Further immunofluorescence results confirmed that the hydrogel improved regenerative quality by promoting mature angiogenesis with a vessel density of 116/mm ² and switching macrophages toward anti-inflammatory M2 phenotype. Systemic biosafety evaluation via major organ histological staining validated favorable biocompatibility without obvious organ toxicity. In conclusion, this multifunctional NO-releasing GelMA/L-Arg hydrogel represents a promising candidate for clinical wound dressing applications.",
  "abstract_shown": true,
  "affiliations": [
    "Burn and Plastic Surgery Department, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yi Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongdong Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiyan Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Guojun Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Weixi Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Weiyu Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6q1mcsngm7svd.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1970915",
  "fulltext_url": null,
  "id": "6q1mcsngm7svd",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1970915/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7223663784",
  "pdf_url": "https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1970915/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6q1mcsngm7svd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1970915",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1970915/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1663-9812",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "ROS-responsive GelMA/L-Arginine hydrogel with locally sustained NO release for accelerated skin wound healing",
  "title_text": "ROS-responsive GelMA/L-Arginine hydrogel with locally sustained NO release for accelerated skin wound healing",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:06Z",
  "url": "https://research.draconitic.com/paper/6q1mcsngm7svd",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}