{
  "abstract": "Objective\n\nTo investigate the acceptance of Tuberculosis preventive treatment (TPT) and the factors associated with treatment acceptance among individuals aged ≥60 years that screened positive for latent tuberculosis infection (LTBI) in Huzhou city, Zhejiang Province of China, and to provide scientific evidence for TPT implementation in this population.Methods\n\nOlder adults aged ≥60 years with LTBI were recruited through community-based health examinations and screening of close contacts of active tuberculosis patients. Univariate and multivariate Logistic regression analyses were performed to identify factors associated with TPT acceptance.Results\n\nOf the 620 participants enrolled, 430 (69.35%) accepted TPT. Among the participants, 354 (57.09%) were male, 192 (30.96%) were aged over 70 years, 593 (95.65%) were married, 499 (80.48%) resided in rural areas, 577 (93.06%) had an education level of junior high school or below, 135 (21.77%) smoked daily or occasionally, and 152 (24.52%) consumed alcohol occasionally or at least twice weekly. Multivariate Logistic regression analysis revealed that participants with a household size of ≤3 persons (aOR: 1.88; 95% CI: 1.15-3.07), an annual household income of ≤150, 000 CNY (aOR: 2.24; 95% CI: 1.33-3.77), and a history of underlying diseases (aOR: 1.86; 95% CI: 1.16-2.99) were more likely to accept TPT.Conclusion\n\nThe TPT acceptance rate among older adults aged ≥60 years with LTBI in Huzhou was relatively high. Acceptance was independently associated with household structure, economic status, and health status. Smaller household size (≤3 persons), lower annual household income (≤150, 000 CNY), and the presence of underlying diseases were independently associated with TPT acceptance in this population. Targeted intervention strategies should be developed for older adults from larger households, those with better economic conditions, and those without underlying diseases to improve overall TPT coverage.",
  "abstract_shown": true,
  "affiliations": [
    "Department of HIV/TB Control and Prevention, Huzhou Center for Disease Control and Prevention, Huzhou, China.",
    "Department of Tuberculosis Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.",
    "Department of Disease Control and Prevention, Huzhou Municipal Health Commission, Huzhou, China.",
    "Department of HIV/TB Control and Prevention, Wuxing District Center for Disease Control and Prevention, Huzhou, China.",
    "Department of HIV/TB Control and Prevention, Nanxun District Center for Disease Control and Prevention, Huzhou, China.",
    "Department of HIV/TB Control and Prevention, Deqing County Center for Disease Control and Prevention, Huzhou, China.",
    "Department of HIV/TB Control and Prevention, Changxing County Center for Disease Control and Prevention, Huzhou, China.",
    "Department of HIV/TB Control and Prevention, Anji County Center for Disease Control and Prevention, Huzhou, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhongrong Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhipeng Zu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiuxiu Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "XinYi Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Wei Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Pingming Zheng"
    },
    {
      "affs": [
        2
      ],
      "name": "Dong Wen"
    },
    {
      "affs": [
        0
      ],
      "name": "Feilin Ren"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhongming Ding"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming Gan"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyan Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Sichao Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Yikun Kong"
    },
    {
      "affs": [
        4
      ],
      "name": "Guojun Jiang"
    },
    {
      "affs": [
        5
      ],
      "name": "Jianliang Fan"
    },
    {
      "affs": [
        6
      ],
      "name": "Jiasheng Qin"
    },
    {
      "affs": [
        7
      ],
      "name": "Jicun You"
    },
    {
      "affs": [
        0
      ],
      "name": "Meihua Jin"
    },
    {
      "affs": [
        1
      ],
      "name": "Bin Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Peng Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianyong Shen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6q5jbb7x62k8p.bib",
  "cited_by": 0,
  "doi": "10.3389/fcimb.2026.1967858",
  "fulltext_url": "https://europepmc.org/articles/PMC13713273",
  "id": "6q5jbb7x62k8p",
  "issns": [
    "2235-2988"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952506",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2725|Tuberculosis Research and Epidemiology"
    ]
  ],
  "openalex": "W7221753039",
  "pdf_url": "https://europepmc.org/articles/PMC13713273?pdf=render",
  "pmcid": "PMC13713273",
  "pmid": "42952506",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6q5jbb7x62k8p.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42952506",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952506"
    },
    {
      "first_seen": "2026-10-31T12:23:51Z",
      "native_id": "PMC13713273",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcimb.2026.1967858"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Tuberculosis Research and Epidemiology",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Factors associated with acceptance of preventive treatment among older adults with latent tuberculosis infection in Huzhou, Zhejiang province: a cross-sectional study.",
  "title_text": "Factors associated with acceptance of preventive treatment among older adults with latent tuberculosis infection in Huzhou, Zhejiang province: a cross-sectional study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:58Z",
  "url": "https://research.draconitic.com/paper/6q5jbb7x62k8p",
  "venue": "Frontiers in cellular and infection microbiology",
  "versions": []
}