{
  "abstract": "Zinc porphyrin hydrogen-bonded organic frameworks (ZnTCPP HOFs) are prone to uncontrolled short-range π–π stacking at solid/liquid interfaces, which leads to aggregation-caused quenching (ACQ) and consequently limits their electrochemiluminescence (ECL) efficiency. Current strategies for suppressing ACQ primarily depend on covalent or coordination bonds and often involve laborious synthesis. Addressing this challenge from the perspective of colloid and interface science, this study introduces a chitosan (CS)–DMF counter-solvent precipitation strategy. This approach reorganizes the hydrogen-bond network and fosters electrostatic association between CS and the carboxyl groups of ZnTCPP HOFs, thereby facilitating a controlled transformation of bulk crystals into micro/nano-aggregates. This synergistic effect suppresses short-range π–π stacking while enhancing long-range aggregation-induced emission (AIE), leading to a significant improvement in ECL efficiency without the need for an additional co-reaction promoter. On this basis, an aptamer-based ECL sensor was developed for the ultrasensitive detection of 5F-EDMB-PINACA, achieving a limit of detection of 8.61 × 10 -16 g/L and a linear range spanning nine orders of magnitude. These findings underscore the efficacy of colloidal-interface regulation in ECL sensing.",
  "abstract_shown": true,
  "affiliations": [
    "Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering",
    "Changzhou University",
    "Changzhou University Huaide College",
    "Institute of Forensic Science",
    "Changzhou Municipal Security Bureau"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yanpei Zhang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ding Jiang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Bingxue Fan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Mingyang Han"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Suran Tian"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Haibo Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhidong Chen",
      "orcid": "0000-0002-9383-9563"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6qh2xnkrfyevz.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009172/v1",
  "fulltext_url": null,
  "id": "6qh2xnkrfyevz",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009172/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Advanced biosensing and bioanalysis techniques"
    ]
  ],
  "openalex": "W7213952870",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009172/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/6qh2xnkrfyevz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.26434/chemrxiv.15009172",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009172/v4"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Advanced biosensing and bioanalysis techniques",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Interfacial Solvent Engineering of Zinc Porphyrin Hydrogen-Bonded Organic Frameworks Enables Aggregation-Enhanced Electrochemiluminescence for Synthetic Cannabinoid Sensing",
  "title_text": "Interfacial Solvent Engineering of Zinc Porphyrin Hydrogen-Bonded Organic Frameworks Enables Aggregation-Enhanced Electrochemiluminescence for Synthetic Cannabinoid Sensing",
  "type": "preprint",
  "updated_at": "2026-10-31T00:20:31Z",
  "url": "https://research.draconitic.com/paper/6qh2xnkrfyevz",
  "venue": "ChemRxiv",
  "versions": []
}