{
  "abstract": "Background and Objectives: Healthcare-associated infections (HAIs) caused by Pseudomonas aeruginosa represent a challenge for healthcare systems worldwide, with significant incidence, high mortality, and increasing antibiotic resistance. This paper aims to describe and analyze the epidemiology of HAI cases with Pseudomonas aeruginosa in a tertiary neurosurgical hospital in the northeastern region of Romania during 2020-2024. Materials and Methods: Study inclusion criteria were patients of any age (as the hospital also admits pediatric patients from the region) and a diagnosis of P. aeruginosa HAI, with a signed informed consent form by the adult patient or relatives for pediatric patients. Results: During 2020-2024, 163 cases of P. aeruginosa HAIs were identified. The annual incidence decreased from 4.41‱ in 2020 to 2.37‱ in 2024 (p = 0.0038). Most cases occurred in the intensive care unit (ICU) (119/163; 73.0%), followed by neurosurgery wards (37/163; 22.7%). Overall, 110 cases (67.5%) occurred in men and 53 (32.5%) in women. The analysis also showed a predominance of late-onset cases and the presence of antimicrobial-resistant phenotypes among the identified P. aeruginosa isolates. Conclusions: This study provides an integrated epidemiological characterization of P. aeruginosa HAIs in a regional neurosurgical hospital, highlighting the predominance of ICU-associated cases, late-onset infections, and antimicrobial-resistant phenotypes. These findings support the need for continued epidemiological surveillance and antimicrobial resistance monitoring in high-risk neurosurgical settings.",
  "abstract_shown": true,
  "affiliations": [
    "Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, \"Dunărea de Jos\" University of Galați, 47 Domnească Street, 800008 Galati, Romania.",
    "Faculty of Medicine and Pharmacy, \"Dunărea de Jos\" University of Galați, 47 Domnească Street, 800008 Galati, Romania.",
    "Faculty of Medicine, Ovidius University Constanța, 900740 Constanta, Romania.",
    "Faculty of Medicine, \"Grigore T. Popa\" University of Medicine and Pharmacy, 16 Universității Street, 700115 Iasi, Romania.",
    "Department of Preventive Medicine and Interdisciplinarity, Faculty of Medicine, \"Grigore T. Popa\" University of Medicine and Pharmacy, 16, Universității Street, 700115 Iasi, Romania."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nicoleta Luchian"
    },
    {
      "affs": [
        1
      ],
      "name": "Cristian Guțu",
      "orcid": "0009-0000-5081-3577"
    },
    {
      "affs": [
        2
      ],
      "name": "Camer Salim"
    },
    {
      "affs": [
        1
      ],
      "name": "Alina Pleșea-Condratovici",
      "orcid": "0000-0002-2710-7284"
    },
    {
      "affs": [
        3
      ],
      "name": "Marius Gabriel Dabija",
      "orcid": "0000-0002-3189-2027"
    },
    {
      "affs": [
        3
      ],
      "name": "Mădălina Irina Ciuhodaru"
    },
    {
      "affs": [
        0
      ],
      "name": "Mădălina Duceac Covrig",
      "orcid": "0009-0002-3092-2324"
    },
    {
      "affs": [
        1
      ],
      "name": "Constantin Marcu"
    },
    {
      "affs": [
        4
      ],
      "name": "Irina Luciana Gurzu",
      "orcid": "0000-0003-3095-3497"
    },
    {
      "affs": [
        1
      ],
      "name": "Petruța Iuliana Moraru"
    },
    {
      "affs": [
        1
      ],
      "name": "Mădălina Nicoleta Matei"
    },
    {
      "affs": [
        1
      ],
      "name": "Letiția Doina Duceac",
      "orcid": "0000-0002-1652-2618"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6qk4zchwahr9s.bib",
  "cited_by": 0,
  "doi": "10.3390/medicina62102019",
  "fulltext_url": "https://europepmc.org/articles/PMC13707045",
  "id": "6qk4zchwahr9s",
  "issns": [
    "1010-660X",
    "1648-9144"
  ],
  "landing_url": "https://europepmc.org/article/MED/42942550",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2706|Nosocomial Infections in ICU"
    ]
  ],
  "openalex": "W7222974975",
  "pdf_url": "https://europepmc.org/articles/PMC13707045?pdf=render",
  "pmcid": "PMC13707045",
  "pmid": "42942550",
  "published": "2026-10-19",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/6qk4zchwahr9s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42942550",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42942550"
    },
    {
      "first_seen": "2026-10-31T14:21:33Z",
      "native_id": "038dcf2eb69a44fea0041ff19f004adb",
      "source": "doaj",
      "url": "https://doi.org/10.3390/medicina62102019"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2706|Nosocomial Infections in ICU",
      "subfield": "general"
    }
  ],
  "title": "Healthcare-Associated Infections with Pseudomonas spp. in a Neurosurgical Hospital: Epidemiological and Clinical Insights.",
  "title_text": "Healthcare-Associated Infections with Pseudomonas spp. in a Neurosurgical Hospital: Epidemiological and Clinical Insights.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:21:33Z",
  "url": "https://research.draconitic.com/paper/6qk4zchwahr9s",
  "venue": "Medicina (Kaunas, Lithuania)",
  "versions": []
}