{
  "abstract": "The blood plasma proteome is a rich reservoir of potential biomarkers, yet its analysis is hindered by a protein concentration dynamic range exceeding ten orders of magnitude. Traditional fractionation and enrichment methods often present limitations in detecting rare proteins masked by the presence of abundant proteins. A promising frontier technology has emerged to overcome such limitations: leveraging nanoparticle protein coronas to enrich low-abundance plasma proteins and unveil previously inaccessible layers of the proteome. This Perspective highlights the capabilities of the protein corona technology in enhancing proteome coverage, addresses its current limitations and outlines future directions in proteoform analysis and causal inference. Proteomics has long suffered from artifacts and effects due to the wide range of protein concentrations. Here, the authors offer a perspective on the use of nanoparticles to enhance the detection of low-abundance proteins by using the formation of the protein corona.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden",
    "Department of Chemistry, Michigan State University, East Lansing, MI, USA",
    "Department of Computer Science and Engineering, Michigan State University, East Lansing, MI, USA",
    "Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA",
    "Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA",
    "Human Proteomics Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA",
    "Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Melbourne, VIC, Australia",
    "Melbourne Medical School, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Melbourne, VIC, Australia",
    "The Graeme Clark Institute, The University of Melbourne, Melbourne, VIC, Australia",
    "Children's Heart Institute, McGovern Medical School, UTHealth, Houston, TX, USA",
    "Centre for Nanotechnology in Medicine, Faculty of Biology, Medicine & Health, The University of Manchester, Manchester, UK",
    "Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain",
    "Institute of Neuroscience, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain",
    "Nanomedicine Lab, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Barcelona, Spain",
    "Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA",
    "Department of Chemical Engineering, The University of Melbourne, Parkville, VIC, Australia. fcaruso@unimelb.edu.au",
    "Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, MI, USA. mahmou22@msu.edu",
    "Precision Health Program, Michigan State University, East Lansing, MI, USA. mahmou22@msu.edu"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Amir Ata Saei",
      "orcid": "0000-0002-2639-6328"
    },
    {
      "affs": [
        1
      ],
      "name": "Bahareh Ghaffari",
      "orcid": "0000-0003-0126-334X"
    },
    {
      "affs": [
        2
      ],
      "name": "Borzoo Bonakdarpour",
      "orcid": "0000-0003-1800-5419"
    },
    {
      "affs": [
        1
      ],
      "name": "Liangliang Sun",
      "orcid": "0000-0001-8939-5042"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Ying Ge",
      "orcid": "0000-0001-5211-6812"
    },
    {
      "affs": [
        6,
        7,
        8
      ],
      "name": "David R. Nisbet",
      "orcid": "0000-0002-1343-0769"
    },
    {
      "affs": [
        9
      ],
      "name": "Vahid Serpooshan",
      "orcid": "0000-0002-5304-095X"
    },
    {
      "affs": [
        10,
        11,
        12,
        13
      ],
      "name": "Kostas Kostarelos",
      "orcid": "0000-0002-2224-6672"
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    {
      "affs": [
        1
      ],
      "name": "Babak Borhan",
      "orcid": "0000-0002-3193-0732"
    },
    {
      "affs": [
        14
      ],
      "name": "Catherine Jones Murphy",
      "orcid": "0000-0001-7066-5575"
    },
    {
      "affs": [
        15
      ],
      "name": "Frank Caruso",
      "orcid": "0000-0002-0197-497X"
    },
    {
      "affs": [
        16,
        17
      ],
      "name": "Morteza Mahmoudi",
      "orcid": "0000-0002-2575-9684"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6qpsta7qd06nr.bib",
  "cited_by": 6,
  "doi": "10.1038/s41467-026-74426-w",
  "fulltext_url": null,
  "id": "6qpsta7qd06nr",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-74426-w",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "1607|Advanced Proteomics Techniques and Applications"
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  "pdf_url": "https://www.nature.com/articles/s41467-026-74426-w.pdf",
  "pmcid": "PMC13269704",
  "pmid": "42297805",
  "published": "2026-06-15",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/6qpsta7qd06nr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:44Z",
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      "url": "https://doi.org/10.1038/s41467-026-74426-w"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Advanced Proteomics Techniques and Applications",
      "subfield": "physical"
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  ],
  "title": "Leveraging nanoparticle protein corona to advance plasma proteome profiling",
  "title_text": "Leveraging nanoparticle protein corona to advance plasma proteome profiling",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:39Z",
  "url": "https://research.draconitic.com/paper/6qpsta7qd06nr",
  "venue": "Nature Communications",
  "versions": []
}