{
  "abstract": "Characterization of cell type emergence during human cortical development, which enables unique human cognition, has focused primarily on anatomical and transcriptional characterizations. Metabolic processes in the human brain that allow for rapid expansion, but contribute to vulnerability to neurodevelopmental disorders, remain largely unexplored. We performed a variety of metabolic assays in primary tissue and stem cell derived cortical organoids and observed dynamic changes in core metabolic functions, including an unexpected increase in glycolysis during late neurogenesis. By depleting glucose levels in cortical organoids, we increased outer radial glia, astrocytes, and inhibitory neurons. We found the pentose phosphate pathway (PPP) was impacted in these experiments and leveraged pharmacological and genetic manipulations to recapitulate these radial glia cell fate changes. These data identify a new role for the PPP in modulating radial glia cell fate specification and generate a resource for future exploration of additional metabolic pathways in human cortical development.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA",
    "Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA",
    "Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA",
    "Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA",
    "School of Biological and Health Systems Engineering, Arizona State University, Phoenix, AZ, USA",
    "Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA",
    "Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: hchristofk@mednet.ucla.edu",
    "Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: abhaduri@mednet.ucla.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 27,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jessenya Mil",
      "orcid": "0000-0002-3040-0211"
    },
    {
      "affs": [
        0
      ],
      "name": "Jose A. Soto",
      "orcid": "0000-0002-2246-8961"
    },
    {
      "affs": [
        0
      ],
      "name": "Abigail S. Krall"
    },
    {
      "affs": [
        0
      ],
      "name": "Julia Peloggia",
      "orcid": "0000-0003-4635-3920"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Frigui",
      "orcid": "0000-0002-6627-8668"
    },
    {
      "affs": [
        0
      ],
      "name": "Olivia S. Fong"
    },
    {
      "affs": [
        1
      ],
      "name": "Laila Sathe",
      "orcid": "0000-0003-1016-3295"
    },
    {
      "affs": [
        0
      ],
      "name": "Nedas Matulionis",
      "orcid": "0000-0001-7624-3090"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesca Day"
    },
    {
      "affs": [
        2
      ],
      "name": "Linsey Stiles",
      "orcid": "0000-0002-1514-458X"
    },
    {
      "affs": [
        1
      ],
      "name": "Katrina P. Montales",
      "orcid": "0009-0001-4260-2902"
    },
    {
      "affs": [
        0
      ],
      "name": "Daria J. Azizad",
      "orcid": "0009-0006-7015-9027"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlos E. Gonzalez"
    },
    {
      "affs": [
        0
      ],
      "name": "Elisa Fazzari",
      "orcid": "0000-0001-5651-8587"
    },
    {
      "affs": [
        0
      ],
      "name": "Matthew X. Li",
      "orcid": "0009-0009-0539-7389"
    },
    {
      "affs": [
        0
      ],
      "name": "Patricia R. Nano",
      "orcid": "0000-0002-5507-2656"
    },
    {
      "affs": [
        0
      ],
      "name": "Antoni Andreu Martija",
      "orcid": "0000-0003-4293-6002"
    },
    {
      "affs": [
        0
      ],
      "name": "Cesar A. Perez-Ramirez"
    },
    {
      "affs": [
        0
      ],
      "name": "Claudia V. Nguyen",
      "orcid": "0000-0002-4796-6182"
    },
    {
      "affs": [
        3
      ],
      "name": "Brittney D Wick",
      "orcid": "0000-0002-6562-395X"
    },
    {
      "affs": [
        0
      ],
      "name": "Weihong Ge",
      "orcid": "0000-0003-2218-6291"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryan L. Kan",
      "orcid": "0000-0003-1162-8365"
    },
    {
      "affs": [
        4
      ],
      "name": "Madeline G. Andrews",
      "orcid": "0000-0002-5154-5081"
    },
    {
      "affs": [
        3
      ],
      "name": "Maximilian Haeussler",
      "orcid": "0000-0001-8721-8253"
    },
    {
      "affs": [
        5
      ],
      "name": "Michael F. Wells",
      "orcid": "0000-0002-1367-2565"
    },
    {
      "affs": [
        6
      ],
      "name": "Heather R. Christofk",
      "orcid": "0000-0002-8662-4425"
    },
    {
      "affs": [
        7
      ],
      "name": "Aparna Bhaduri",
      "orcid": "0000-0003-4625-6899"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6qpwaxje49txp.bib",
  "cited_by": 11,
  "doi": "10.1016/j.cell.2026.07.023",
  "fulltext_url": null,
  "id": "6qpwaxje49txp",
  "issns": [
    "0092-8674",
    "1097-4172"
  ],
  "landing_url": "https://doi.org/10.1016/j.cell.2026.07.023",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2806|Neurogenesis and neuroplasticity mechanisms"
    ]
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  "openalex": "W7172409250",
  "pdf_url": "https://www.cell.com/cell/pdf/S0092-8674(26)00821-4.pdf",
  "pmcid": "PMC11952424",
  "pmid": "40161647",
  "published": "2026-08-04",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/6qpwaxje49txp.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T13:21:01Z",
      "native_id": "W7172409250",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.cell.2026.07.023"
    }
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2806|Neurogenesis and neuroplasticity mechanisms",
      "subfield": "neuroscience"
    }
  ],
  "title": "Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions",
  "title_text": "Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:12Z",
  "url": "https://research.draconitic.com/paper/6qpwaxje49txp",
  "venue": "Cell",
  "versions": []
}