{
  "abstract": "Background\n\nHypertriglyceridemic acute pancreatitis (HTG-AP) is accompanied by significant metabolic abnormalities, but few studies have investigated whether a composite measure of this metabolic burden is associated with severe acute pancreatitis (SAP). The metabolic score for insulin resistance (METS-IR), derived from fasting glucose, high-density lipoprotein cholesterol, triglycerides, and body mass index, can be calculated from routinely available clinical data without requiring an insulin assay. However, its association with SAP in HTG-AP remains poorly characterized.Objective\n\nThis study investigates the association between admission METS-IR and SAP in patients with HTG-AP and assesses the robustness of this association through subgroup and sensitivity analyses.Methods\n\nWe retrospectively assembled a single-center cohort of 456 adults admitted with HTG-AP between January 2019 and July 2025. Logistic regression evaluated METS-IR as a continuous exposure and in quartiles. Restricted cubic splines, subgroup analyses, and sensitivity analyses were performed. Exploratory ROC analyses compared apparent discrimination with TyG, TyG-BMI, and BISAP.Results\n\nSAP occurred in 78 of 456 patients (17.1%). Median METS-IR was 69.99 (IQR, 61.92-83.67) in the SAP group and 58.18 (IQR, 51.47-66.46) in the non-SAP group. In Model 3, each one-point increase in METS-IR was associated with higher odds of SAP (OR, 1.06; 95% CI, 1.04-1.08). After additional adjustment for TG, TG/HDL-C, and TyG, the estimate was attenuated (OR, 1.03; 95% CI, 0.997-1.064; P = 0.073). Apparent AUCs were 0.730 for METS-IR, 0.720 for TyG, and 0.758 for BISAP; neither paired comparison showed a statistically significant difference. In the three-category analysis, the METS-IR association was stronger for SAP vs. MAP than for MSAP vs. MAP.Conclusion\n\nHigher admission METS-IR was independently associated with higher odds of SAP in patients with HTG-AP. METS-IR may provide a readily available measure of metabolic burden for early clinical assessment of patients with HTG-AP, although its clinical utility requires confirmation in prospective multicenter studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Bishan Hospital of Chongqing Medical University , ,",
    "Department of Endocrinology, Bishan Hospital of Chongqing Medical University , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ziyi Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Changwei Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuanxia Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chenghu Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Rong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6qtjavtb9nzqy.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1999625",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717400/?tool=EBI",
  "id": "6qtjavtb9nzqy",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13717400",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2746|Pancreatitis Pathology and Treatment"
    ]
  ],
  "openalex": "W7222075540",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717400/pdf/?tool=EBI",
  "pmcid": "PMC13717400",
  "pmid": "42959687",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6qtjavtb9nzqy.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13717400",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717400"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42959687",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959687"
    },
    {
      "first_seen": "2026-11-02T12:21:43Z",
      "native_id": "PMC13717400",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1999625"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Pancreatitis Pathology and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Admission METS-IR in relation to severe acute pancreatitis among patients with hypertriglyceridemic acute pancreatitis: a retrospective cohort study",
  "title_text": "Admission METS-IR in relation to severe acute pancreatitis among patients with hypertriglyceridemic acute pancreatitis: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:43Z",
  "url": "https://research.draconitic.com/paper/6qtjavtb9nzqy",
  "venue": "Frontiers in medicine",
  "versions": []
}