{
  "abstract": "PURPOSE: The purpose of this study was to analyze retinochoroidal parameters in patients with obstructive sleep apnea syndrome (OSAS) using spectral-domain optical coherence tomography (SD-OCT) and evaluate their relationship with disease severity. MATERIALS AND METHODS: This cross-sectional observational study included 60 OSAS patients diagnosed by overnight polysomnography and 60 age-matched healthy controls. The OSAS group was subdivided based on apnea–hypopnea index into mild (n = 18), moderate (n = 28), and severe (n = 14) categories. SD-OCT measurements included retinal nerve fiber layer (RNFL) thickness, ganglion cell–inner plexiform layer (GC-IPL) thickness, subfoveal choroidal thickness, and central macular thickness. RESULTS: OSAS patients showed significant thinning in average RNFL (94.7 ± 7.84 μm vs. 98.93 ± 7.67 μm, 95% confidence interval [CI]: 1.43–7.03, P = 0.003) and GC-IPL thicknesses (80.03 ± 3.11 μm vs. 82.1 ± 2.05 μm, 95% CI: 1.12–3.02, P < 0.001) compared to controls. Severity-based analysis revealed progressive thinning across all parameters, with the strongest correlations observed between disease severity and GC-IPL (r = −0.979) and RNFL parameters (r = −0.922). The most significant differences were consistently found between mild and severe OSAS groups (P < 0.001). CONCLUSION: Significant retinochoroidal alterations occur in OSAS patients, with changes correlating to disease severity. The distinctive pattern of retinal layer thinning, particularly in superotemporal RNFL and superior GC-IPL, demonstrates an association with OSAS severity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Prabhjot Singh"
    },
    {
      "name": "Ashok Kumar Sharma"
    },
    {
      "name": "Vijay Kumar Sharma"
    },
    {
      "name": "Vikas Ambiya"
    },
    {
      "name": "Jyothi Nandanan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6r203vaggf953.bib",
  "cited_by": 0,
  "doi": "10.4103/tjo.tjo-d-25-00097",
  "fulltext_url": "https://www.ovid.com/jnls/tjop/fulltext/10.4103/tjo.tjo-d-25-00097~retinochoroidal-structural-alterations-in-obstructive-sleep",
  "id": "6r203vaggf953",
  "issns": [
    "2211-5056",
    "2211-5072"
  ],
  "landing_url": "https://doi.org/10.4103/tjo.tjo-d-25-00097",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RE1-994"
    ],
    [
      "openalex",
      "2731|Glaucoma and retinal disorders"
    ]
  ],
  "openalex": "W7168394460",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Wolters Kluwer Medknow Publications",
  "ris": "https://research.draconitic.com/paper/6r203vaggf953.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:56Z",
      "native_id": "6e913e93680b491abab9cc394a81d54c",
      "source": "doaj",
      "url": "https://doi.org/10.4103/tjo.tjo-d-25-00097"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Glaucoma and retinal disorders",
      "subfield": "general"
    }
  ],
  "title": "Retinochoroidal structural alterations in obstructive sleep apnea: A spectral domain optical coherence tomography study",
  "title_text": "Retinochoroidal structural alterations in obstructive sleep apnea: A spectral domain optical coherence tomography study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:56Z",
  "url": "https://research.draconitic.com/paper/6r203vaggf953",
  "venue": "Taiwan Journal of Ophthalmology",
  "versions": []
}