{
  "abstract": "Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen known to cause infections of diverse severity, ranging from mild ulceration of mucosal and dermal tissues to life-threatening viral encephalitis. In most cases, standard treatment with acyclovir is sufficient to manage the disease progression. However, the emergence of ACV-resistant strains drives the need for new therapeutics and molecular targets. HSV-1 VP24 is a protease indispensable for the assembly of mature virions and, as such, constitutes an interesting target for the therapy. In this study, we present novel compounds, KI207M and EWDI/39/55BF, that block the activity of VP24 protease and consequently inhibit HSV-1 infection in vitro and in vivo. The inhibitors were shown to prevent the egress of viral capsids from the cell nucleus and suppress the cell-to-cell spread of the infection. They were also proven effective against ACV-resistant HSV-1 strains. Considering their low toxicity and high antiviral potency, the novel VP24 inhibitors could provide an alternative for treating ACV-resistant infections or a drug to be used in combined, highly effective therapy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Magdalena Pachota"
    },
    {
      "name": "Renata Grzywa"
    },
    {
      "name": "Jakub Iwanejko"
    },
    {
      "name": "Aleksandra Synowiec"
    },
    {
      "name": "Dominika Iwan"
    },
    {
      "name": "Karolina Kamińska"
    },
    {
      "name": "Marcin Skoreński"
    },
    {
      "name": "Ewa Bielecka"
    },
    {
      "name": "Krzysztof Szczubiałka"
    },
    {
      "name": "Maria Nowakowska"
    },
    {
      "name": "Cameron D Mackereth"
    },
    {
      "name": "Elżbieta Wojaczyńska"
    },
    {
      "name": "Marcin Sieńczyk"
    },
    {
      "name": "Krzysztof Pyrć"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6r5en4sfgxhz9.bib",
  "cited_by": 13,
  "doi": "10.1016/j.antiviral.2023.105604",
  "fulltext_url": null,
  "id": "6r5en4sfgxhz9",
  "issns": [
    "0166-3542"
  ],
  "landing_url": "https://hal.science/hal-05824613v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
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    ],
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      "0.sdv"
    ],
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      "1.chim.ther"
    ],
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      "1.sdv.mhep"
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      "1.sdv.mp"
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      "openalex",
      "2713|Herpesvirus Infections and Treatments"
    ]
  ],
  "openalex": "W4364378071",
  "pdf_url": "https://hal.science/hal-05824613/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/6r5en4sfgxhz9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:59Z",
      "native_id": "hal-05824613",
      "source": "hal",
      "url": "https://hal.science/hal-05824613v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.mp",
      "subfield": "microbiology"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.ther",
      "subfield": "medicinal"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.mi",
      "subfield": "infectious-disease"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.sp",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Novel inhibitors of HSV-1 protease effective in vitro and in vivo",
  "title_text": "Novel inhibitors of HSV-1 protease effective in vitro and in vivo",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:59Z",
  "url": "https://research.draconitic.com/paper/6r5en4sfgxhz9",
  "venue": "Antiviral Research",
  "versions": []
}