{
  "abstract": "Background: Combining CDK 4/6 inhibitors with endocrine therapy (ET) extends progression-free survival (PFS) and overall survival (OS) in hormone receptor (HR) positive, human epidermal growth factor receptor-2 (HER2) negative metastatic breast cancer. We aimed to explore the relationship between metabolic tumor volume (MTV), total lesion glycolysis (TLG), and PFS/OS in these patients.\n\nMethods: MTV and TLG were measured from baseline 18 F-fluorodeoxyglucose (18-FDG) positron emission tomography/computed tomography (PET/CT) of 87 HR-positive/HER2-negative metastatic breast cancer patients and their effects on survival were analyzed using Kaplan-Meier methods.\n\nResults: The median OS was 42.0 months for patients with MTV < 121.7 cm³ and 24.6 months with ≥ 121.7 cm3 (p = 0.001). The median OS was 40.3 months for patients with TLG < 732.4 g and 24.6 months with ≥ 732.4 g (p = 0.006). The median OS for patients with an ECOG score of 0 was 53.6 months, while for those with an ECOG score of 1–2, it was 26.4 months (p = 0.005). Age ≥ 60 years (HR = 5.11, p = 0.002) and ECOG score > 0 (HR = 3.38, p = 0.011) are independent predictors of PFS.\n\nConclusions: Baseline 18 F-FDG PET/CT may provide prognostic insights in HR+/HER2- metastatic breast cancer. High MTV and TLG are associated with poorer OS in univariate analyses but not in multivariable analyses. ECOG score > 0 and age ≥ 60 years are independent predictors of PFS.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine, Department of Nuclear Medicine, Erciyes University, Kayseri, 38039 Turkey",
    "Faculty of Medicine, Department of Medical Oncology, Recep Tayyip Erdoğan University, Rize, 53020 Turkey",
    "Faculty of Medicine, Department of Nuclear Medicine, Recep Tayyip Erdoğan University, Rize, 53020 Turkey"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ogün Bülbül",
      "orcid": "0000-0002-4154-8801"
    },
    {
      "affs": [
        1
      ],
      "name": "Esra Aydin"
    },
    {
      "affs": [
        2
      ],
      "name": "Demet Nak",
      "orcid": "0000-0002-9756-7788"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6rhtwj4hvj9nt.bib",
  "cited_by": 0,
  "doi": "10.1007/s11845-026-04505-w",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13740033/",
  "id": "6rhtwj4hvj9nt",
  "issns": [
    "0021-1265",
    "1863-4362"
  ],
  "landing_url": "https://doi.org/10.1007/s11845-026-04505-w",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2730|Advanced Breast Cancer Therapies"
    ]
  ],
  "openalex": "W7164999804",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s11845-026-04505-w.pdf",
  "pmcid": "PMC13740033",
  "pmid": "42307707",
  "published": "2026-06-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6rhtwj4hvj9nt.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:21:21Z",
      "native_id": "PMC13740033",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s11845-026-04505-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Advanced Breast Cancer Therapies",
      "subfield": "oncology"
    }
  ],
  "title": "Relationship between overall survival and progression-free survival with 18 F-FDG PET/CT metabolic parameters in metastatic breast cancer patients treated with CDK 4/6 inhibitors",
  "title_text": "Relationship between overall survival and progression-free survival with 18 F-FDG PET/CT metabolic parameters in metastatic breast cancer patients treated with CDK 4/6 inhibitors",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:21:21Z",
  "url": "https://research.draconitic.com/paper/6rhtwj4hvj9nt",
  "venue": "Irish Journal of Medical Science",
  "versions": []
}