{
  "abstract": "Doxorubicin-induced cardiomyopathy (DIC) is a severe complication following anthracycline chemotherapy, and its main pathogenesis is inflammatory responses and ferroptosis. This study constructed hyaluronic acid-based macrophage biomimetic nanoparticles (M@HCDA) to co-delivery of Celastrol (Cel) and siADAM17 for the treatment of DIC. This research revealed that Cel exerted an anti-ferroptosis effect by regulating GPX4 and SLC7A11, while siADAM17 inhibited TAK1-MAPK pathway activation by silencing ADAM17. Meanwhile, the synergistic effect of Cel and siADAM17 significantly alleviated oxidative stress, myocardial fibrosis, apoptosis, and mitochondrial dysfunction, thereby relieving myocardial injury caused by DOX-induced cardiotoxicity and providing effective early cardioprotection. In vitro and in vivo experiments indicated that M@HCDA exhibited good stability, biocompatibility, and targeting capability, showing the clinical application potential. The design and development of M@HCDA provide new experimental evidence and candidate strategy for treating DIC.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Integrative Medicine, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China; College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China",
    "College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China",
    "College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China; Corresponding author. College of Pharmacy, Dalian Medical University, Dalian, 116044, China.",
    "Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116044, China; Corresponding author.Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116044, China.",
    "College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China; College of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, China; Corresponding author. College of Pharmacy, Dalian Medical University, Dalian, 116044, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qiyu Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Tianyu Guo"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuna Xue"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhibo Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinyan Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Qing Cai"
    },
    {
      "affs": [
        2
      ],
      "name": "Ning Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Bo Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Jinyong Peng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6rrhxv6sbhy53.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103779",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2590006426010240",
  "id": "6rrhxv6sbhy53",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://doi.org/10.1016/j.mtbio.2026.103779",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full Length Article"
    ],
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7223284933",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722028/pdf/?tool=EBI",
  "pmcid": "PMC13722028",
  "pmid": "42965117",
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/6rrhxv6sbhy53.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:19Z",
      "native_id": "522276e796974af7aaedee9bb43db77e",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.mtbio.2026.103779"
    },
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13722028",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722028"
    },
    {
      "first_seen": "2026-11-03T12:22:37Z",
      "native_id": "PMC13722028",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.mtbio.2026.103779"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Targeted delivery of celastrol and siRNA via macrophage biomimetic nanoparticles for doxorubicin-induced cardiomyopathy therapy",
  "title_text": "Targeted delivery of celastrol and siRNA via macrophage biomimetic nanoparticles for doxorubicin-induced cardiomyopathy therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:37Z",
  "url": "https://research.draconitic.com/paper/6rrhxv6sbhy53",
  "venue": "Materials Today Bio",
  "versions": []
}