{
  "abstract": "BackgroundThe systemic immune-inflammation index (SII) is a routinely available blood-derived marker with potential prognostic relevance after coronary artery bypass grafting (CABG). We evaluated associations between preoperative SII and postoperative outcomes.\n\nMethodsPubMed, Embase, Scopus and Web of Science were searched to 1 October 2026, with supplementary searches through 14 October 2026. Peer-reviewed observational studies evaluating preoperative SII in adults undergoing CABG were eligible. Methodological quality was assessed using the Newcastle-Ottawa Scale. Compatible categorical associations and exploratory adjusted continuous mortality effects were pooled separately using restricted maximum-likelihood random-effects models; other findings were summarized descriptively.\n\nResultsThirty-one reports were included, with an aggregate sample of 30,976 and possible cohort overlap; five contributed to meta-analysis. Two off-pump cohorts comprising 1,378 patients and 180 atrial-fibrillation events yielded an imprecise crude association with postoperative atrial fibrillation (OR 1.60, 95%CI 0.53-4.82; I2=68%). An exploratory crude synthesis indicated greater intra-aortic balloon pump use with higher SII (OR 2.45, 95%CI 1.16-5.18; I2=51%). Two cohorts with differing follow-up yielded an exploratory adjusted mortality HR of 1.11 (95% Wald CI 1.05-1.18) per study-specific SD increase in log-SII. In one 624-patient cohort, high SII was associated with postoperative acute kidney injury after adjustment (OR 3.35, 95% CI 2.25-4.97).Apparent atrial-fibrillation discrimination varied (AUC 0.587-0.946).\n\nConclusionsPreoperative SII showed associations with selected adverse outcomes after CABG, supporting further evaluation as an accessible prognostic marker. Its incremental value beyond established clinical risk models requires validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, School of Medicine, Iran University of Medical Sciences"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "S. Nourian"
    },
    {
      "name": "K. Jalalian Rad"
    },
    {
      "name": "M. Ghasemi"
    },
    {
      "name": "M. Mosavi Mirkalaie"
    },
    {
      "name": "N. Tayebi"
    },
    {
      "name": "M. M. Ashrafi"
    },
    {
      "name": "M. H. Nourallahzadeh"
    },
    {
      "name": "A. R. Norouzi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6rrs75rfsydez.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.17.26365801",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.17.26365801v1.full",
  "id": "6rrs75rfsydez",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.17.26365801v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "cardiovascular medicine"
    ],
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7223031377",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.17.26365801v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6rrs75rfsydez.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:16Z",
      "native_id": "10.64898/2026.10.17.26365801",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.17.26365801v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:cardiovascular medicine",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Preoperative Systemic Immune-Inflammation Index and Clinical Outcomes After Coronary Artery Bypass Grafting: A Systematic Review and Meta-analysis",
  "title_text": "Preoperative Systemic Immune-Inflammation Index and Clinical Outcomes After Coronary Artery Bypass Grafting: A Systematic Review and Meta-analysis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:16Z",
  "url": "https://research.draconitic.com/paper/6rrs75rfsydez",
  "venue": "medRxiv",
  "versions": []
}