{
  "abstract": "Lung cancer remains one of the leading causes of cancer-related mortality worldwide, characterized by profound metabolic reprogramming that sustains malignant growth, immune evasion, and therapeutic resistance. Aberrant activation of glycolysis, increased fatty acid synthesis and uptake, and dysregulated glutamine metabolism provide energy and biosynthetic substrates while reshaping the tumor microenvironment through lactate accumulation, acidosis, and angiogenic signaling. Experimental and clinical evidence indicates that exercise may modulate aspects of these oncogenic metabolic pathways, enhance mitochondrial oxidative capacity, improve oxygen delivery, and restore systemic metabolic homeostasis. By modulating glycolytic flux, lipid turnover, and amino acid metabolism, exercise exerts comprehensive effects on both tumor cells and the host, alleviating cancer-associated cachexia, improving insulin sensitivity, and suppressing systemic inflammation. Exercise may also enhance immune competence and vascular function, thereby potentially promoting antitumor surveillance and supporting the therapeutic response.Integrated with conventional treatments such as chemotherapy, radiotherapy, and immunotherapy, exercise may serve as a non-pharmacological metabolic adjuvant that increases treatment tolerance, mitigates adverse effects, and improves quality of life. Furthermore, exercise-related metabolic, molecular, and physiological biomarkers, including glucose and lipid indices, insulin sensitivity parameters, irisin, cardiopulmonary performance indicators, and serum glycosylation profiles, offer promising tools for evaluating metabolic states and guiding personalized interventions. Collectively, these findings underscore exercise as a powerful modulator of tumor and host metabolism, aligning with the translational paradigm that bridges mechanistic discovery and clinical application. Future research should focus on defining standardized exercise prescriptions, validating predictive biomarkers, and elucidating subtype-specific responses to facilitate the integration of precision exercise therapy into lung cancer management.",
  "abstract_shown": true,
  "affiliations": [
    "Respiratory and Intensive Care Unit, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China",
    "Respiratory and Intensive Care Unit, Shidong Hospital of Yangpu District, Shanghai, China",
    "Fujian Key Laboratory of Toxicant and Drug Toxicology, Medical College, Ningde Normal University, Ningde, China",
    "Ningde Normal University, Ningde, China",
    "Department of Vascular and Interventional Radiology, Ningde Municipal Hospital of Ningde Normal University, Ningde, China",
    "Fujian Key Laboratory of Medical Bioinformatics, Fujian Medical University, Fuzhou, China",
    "Ningde Clinical Medical College of Fujian Medical University, Ningde, China",
    "Universiti Malaya, Kuala Lumpur, Malaysia",
    "Yale School of Medicine, New Haven, CT USA",
    "Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, USA",
    "Thoracic Department, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China",
    "Emergency and Intensive Care Unit, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China",
    "Emergency and Intensive Care Unit, Shidong Hospital of Yangpu District, Shanghai, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
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        0,
        1
      ],
      "name": "Yonghua Zheng"
    },
    {
      "affs": [
        2,
        3,
        4,
        5,
        6
      ],
      "name": "Yisheng Chen"
    },
    {
      "affs": [
        6
      ],
      "name": "Hanyang Zhao"
    },
    {
      "affs": [
        2,
        3,
        4,
        5,
        6
      ],
      "name": "Guanghui Wu"
    },
    {
      "affs": [
        7
      ],
      "name": "Chen Hua"
    },
    {
      "affs": [
        8
      ],
      "name": "Fu Gao"
    },
    {
      "affs": [
        9
      ],
      "name": "Yue Liu"
    },
    {
      "affs": [
        10
      ],
      "name": "Lei Jiang"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Lihua Dai",
      "orcid": "0009-0003-8278-3175"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6rrz743jq4mqx.bib",
  "cited_by": 0,
  "doi": "10.1186/s12967-026-08665-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737625/",
  "id": "6rrz743jq4mqx",
  "issns": [
    "1479-5876"
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  "landing_url": "https://doi.org/10.1186/s12967-026-08665-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1306|Cancer, Hypoxia, and Metabolism"
    ]
  ],
  "openalex": "W7197046848",
  "pdf_url": null,
  "pmcid": "PMC13737625",
  "pmid": "42983451",
  "published": "2026-08-06",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/6rrz743jq4mqx.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:46Z",
      "native_id": "PMC13737625",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12967-026-08665-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer, Hypoxia, and Metabolism",
      "subfield": "oncology"
    }
  ],
  "title": "Exercise-induced metabolic reprogramming in lung cancer and its translational implications for therapeutic advancement",
  "title_text": "Exercise-induced metabolic reprogramming in lung cancer and its translational implications for therapeutic advancement",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:46Z",
  "url": "https://research.draconitic.com/paper/6rrz743jq4mqx",
  "venue": "Journal of Translational Medicine",
  "versions": []
}