{
  "abstract": "Uterine smooth muscle dysfunction is a common factor in many gynecological conditions, such as endometriosis, adenomyosis, dysmenorrhea, infertility, and labor dystocia. Here, we present a novel high-throughput, optical, low-cost, 96-well plate-based method for measuring myogenic exvivo uterine contractility. We validate this new method on non-pregnant human myometrial samples obtained from hysterectomies by systematically comparing contraction frequency, amplitude, and duration with a standard method using isometric force transducers. We illustrate the potential of this method by screening 8 different compounds, including hormones and pharmacological agents. In particular, we found that antagonists of T-type calcium channels (Z944) and chloride channels (benzbromarone) both decreased contractility in the non-pregnant human uterus. This method will accelerate the pharmacological development of myometrium-specific relaxing agents and provide a powerful tool to investigate the dysregulation of myogenic contractility in gynecological pathologies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Huon Emilie"
    },
    {
      "name": "Rayssac Justine"
    },
    {
      "name": "Lamau Marie-Charlotte"
    },
    {
      "name": "Abo Carole"
    },
    {
      "name": "Dietrich Gauthier"
    },
    {
      "name": "Abrahami Ylann"
    },
    {
      "name": "Kouby Jordan"
    },
    {
      "name": "Adam Julien"
    },
    {
      "name": "Chevalier R. Nicolas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6rv32s59zptj1.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": null,
  "id": "6rv32s59zptj1",
  "issns": [],
  "landing_url": "https://hal.science/hal-05732517v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ib"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.ib.ima"
    ],
    [
      "hal",
      "2.sdv.mhep.geo"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://hal.science/hal-05732517/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6rv32s59zptj1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "hal-05732517",
      "source": "hal",
      "url": "https://hal.science/hal-05732517v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ib",
      "subfield": "systems-synthetic"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.ib.ima",
      "subfield": "imaging"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.geo",
      "subfield": "reproductive-child"
    }
  ],
  "title": "A high-throughput 96-well plate method to measure human uterine contractility",
  "title_text": "A high-throughput 96-well plate method to measure human uterine contractility",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/6rv32s59zptj1",
  "venue": "HAL",
  "versions": []
}