{
  "abstract": "Cross-species immune profiling is limited by marker-panel size and antibody cross-reactivity. We benchmark Quantum Barcoding (QBC), a split-pool oligo-antibody assay, against mass cytometry in human and rhesus macaque blood and integrate separately measured cells using MARIO. The resulting computationally matched profiles carry 174 protein features. Population-frequency concordance was higher in humans (Pearson r = 0.92) than rhesus macaques (r = 0.55), and fusion resolved complementary lineage subsets. Unstimulated signaling conservation varied by lineage, with B-cell profiles correlated across species (Spearman {rho} = 0.70). In the primary PBMC-reference analysis, GM-CSF increased pSTAT5 in human monocytes and dendritic populations and rhesus dendritic cells. Network inference identified convergent pSTAT5-centered connectivity changes in human monocytes and rhesus dendritic cells, including pSTAT1-edge reversal and gained pSTAT3/pERK coupling. These results connect broad surface phenotypes to inferred signaling organization while retaining species- and population-specific differences.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, NV, USA."
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "T.-K. Tan"
    },
    {
      "name": "K. Taylor"
    },
    {
      "name": "F. Zhang"
    },
    {
      "name": "Y. Bai"
    },
    {
      "name": "B. Zhu"
    },
    {
      "name": "M. A. Baertsch"
    },
    {
      "name": "S. A. Anronikov"
    },
    {
      "name": "Z. Bjornson-Hooper"
    },
    {
      "name": "D. L. L. Ho"
    },
    {
      "name": "A. Trejo"
    },
    {
      "name": "H. Nakauchi"
    },
    {
      "name": "A. Czechowicz"
    },
    {
      "name": "F. Steemers"
    },
    {
      "name": "G. P. Nolan"
    },
    {
      "affs": [
        0
      ],
      "name": "D. R. McIlwain"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6rzzycdfrgp28.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.31.763237",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763237v1.full",
  "id": "6rzzycdfrgp28",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763237v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "systems biology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763237v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6rzzycdfrgp28.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:05Z",
      "native_id": "10.64898/2026.10.31.763237",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.31.763237v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:systems biology",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Quantum Barcoding Bridges High-Dimensional Immune Phenotyping with Signaling Responses across Species",
  "title_text": "Quantum Barcoding Bridges High-Dimensional Immune Phenotyping with Signaling Responses across Species",
  "type": "preprint",
  "updated_at": "2026-11-04T00:21:18Z",
  "url": "https://research.draconitic.com/paper/6rzzycdfrgp28",
  "venue": "bioRxiv",
  "versions": []
}