{
  "abstract": "Subject motion and gradient heating-induced frequency and phase offsets result in spectral misalignment during single-voxel MR spectroscopy (SVS) acquisitions. Several methods have been presented to align the spectra, but their performance on a 7T system is unclear. This study aimed to evaluate the practical importance of four retrospective correction methods, namely creatine fitting, residual water, spectral registration, and cross-correlation. SVS data were collected from 127 participants (88/39 female/male, 39{+/-}15 years) using a semi-localization by adiabatic selective refocusing sequence at 7T. Changes in the spectral linewidth, signal-to-noise ratio (SNR), similarity (mean similarity matrix (SImean)), and metabolite quantification (concentration, relative Cramer-Rao lower bounds (rCRLB)) after correction were evaluated. A Wilcoxon signed rank test was used to evaluate these changes. The p-values were adjusted using the false discovery rate (q<0.05) for multiple comparisons. For significant changes, the effect size was further calculated using the Rosenthal formula. The results demonstrated that all correction methods resulted in a significant decrease in the spectral linewidth and significant increases in the spectral SNR and SImean. The mean changes by using the four methods were 0.76-0.99 Hz for the spectral linewidth change (effect sizes:0.73-0.86), 5.79-6.95 for the SNR change (effect size:0.60-0.72), and 0.03-0.03 for the SImean change (effect size:0.87-0.87). The correction also significantly increased the estimates of the metabolite concentrations of PCr, Gln, Glu, GPC, Ins, NAA, Scyllo, and Tau (effect size:0.25-0.57), and significantly decreased the rCRLBs (effect size:0.26-0.42) of Scyllo, Tau, and Gly. These results indicate that each method provides practical benefits in improving the spectral linewidth, SNR, and similarity by showing a strong to very strong effect of the improvements (effect size>0.60). The correction only showed a weak to moderate effect of the changes in the metabolite quantification (effect size<0.60), suggesting that whether the correction results in more reliable metabolite quantification requires further validation.",
  "abstract_shown": true,
  "affiliations": [
    "University of Iowa"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "C.-Y. Lee"
    },
    {
      "name": "J. Xu"
    },
    {
      "name": "B. Yang"
    },
    {
      "name": "R. Noeske"
    },
    {
      "affs": [
        0
      ],
      "name": "V. Magnotta"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6s87re51yrt6x.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.21.753210",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753210v1.full",
  "id": "6s87re51yrt6x",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753210v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioengineering"
    ],
    [
      "openalex",
      "2741|Advanced MRI Techniques and Applications"
    ]
  ],
  "openalex": "W7214025346",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753210v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6s87re51yrt6x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:57Z",
      "native_id": "10.64898/2026.09.21.753210",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753210v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioengineering",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Evaluations of retrospective frequency and phase correction methods for single-voxel MR spectroscopy at 7T",
  "title_text": "Evaluations of retrospective frequency and phase correction methods for single-voxel MR spectroscopy at 7T",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:57Z",
  "url": "https://research.draconitic.com/paper/6s87re51yrt6x",
  "venue": "bioRxiv",
  "versions": []
}