{
  "abstract": "SGMS2, a gene encoding plasma membrane‐resident sphingomyelin synthase 2, SMS2, has emerged as an important determinant of skeletal ossification. Heterozygous SGMS2 variants are associated with a broad spectrum of bone phenotypes, ranging from rickets‐like deformities in childhood to early‐onset osteoporosis, implicating SMS2 in mineralization while the underlying mechanisms are incompletely resolved. As SMS2 activity alters the balance of membrane lipids such as ceramide and sphingomyelin, the effects of SMS2 dysfunction on the skeleton are likely to be multifactorial and distributed across multiple cell types and subcellular compartments. Our recent work has identified SMS2 as a key component of growth plate‐derived matrix vesicles, nanoscale membrane‐bound particles released by skeletal cells that nucleate mineral deposition. Consistent with a functional role in this compartment, inhibition of SMS2 reduced the mineralization capacity of isolated matrix vesicles ex vivo. Collectively, these observations suggest that SMS2 contributes directly to biomineralization within matrix vesicles. Here, we place this emerging finding in the broader context of skeletal biology, disease mechanism, and therapeutic potential.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden",
    "Astrid Lindgren Children's hospital Stockholm Sweden",
    "Folkhälsan Institute of Genetics Folkhälsan Research Center Helsinki Finland",
    "Research Program for Clinical and Molecular Metabolism Faculty of Medicine University of Helsinki Helsinki Finland",
    "Children's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland",
    "Department of Molecular Medicine and Surgery Karolinska Institutet and Clinical Genetics Karolinska University Laboratory Karolinska University Hospital Stockholm Sweden",
    "Molecular Cell Biology Section Department of Biology/Chemistry Osnabrück University Osnabrück Germany",
    "Center for Cellular Nanoanalytics Osnabrück University Osnabrück Germany"
  ],
  "article_type": "article commentary",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Phillip T. Newton"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mathieu Y. Brunet"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jose G. Marchan‐Alvarez"
    },
    {
      "affs": [
        2,
        3,
        4,
        5
      ],
      "name": "Outi Mäkitie"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Joost C. M. Holthuis"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6sfggh4szkadp.bib",
  "cited_by": 0,
  "doi": "10.1002/jex2.70199",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730259/",
  "id": "6sfggh4szkadp",
  "issns": [
    "2768-2811"
  ],
  "landing_url": "https://doi.org/10.1002/jex2.70199",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Commentary"
    ],
    [
      "openalex",
      "2712|Alkaline Phosphatase Research Studies"
    ]
  ],
  "openalex": "W7225173430",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jex2.70199",
  "pmcid": "PMC13730259",
  "pmid": "42979321",
  "published": "2026-11-03",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/6sfggh4szkadp.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:51Z",
      "native_id": "PMC13730259",
      "source": "pmc",
      "url": "https://doi.org/10.1002/jex2.70199"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Alkaline Phosphatase Research Studies",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Matrix Vesicle‐Associated SMS2 as a Novel Mediator of Biomineralization",
  "title_text": "Matrix Vesicle‐Associated SMS2 as a Novel Mediator of Biomineralization",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:51Z",
  "url": "https://research.draconitic.com/paper/6sfggh4szkadp",
  "venue": "Journal of Extracellular Biology",
  "versions": []
}