{
  "abstract": "Objectives: Human immunodeficiency virus (HIV) may impair immune responses to parasitic diseases such as cystic echinococcosis (CE), potentially affecting its clinical presentation and diagnosis.\n\nMethods: We compared the demographics, clinical features, and laboratory findings in patients with hepatic CE (HCE) with and without HIV infection at a tertiary facility in South Africa from 2011 to 2023.\n\nResults: Among 91 patients, 48 (52.7%) had HIV infection and 67 (73.6%) were female, with a median age of 33 years. Abdominal pain was the most common symptom in both groups (∼79%). Abdominal tenderness and palpable mass were the most frequent signs. Jaundice was less common in patients with HIV than those without HIV (P = 0.019) as were bilirubin levels (P = 0.039) and white cell counts (P = 0.038). CE serology was negative in 25.0% of patients with HIV compared with 9.3% without HIV (P = 0.053). Most patients with HIV (88.1%) were receiving antiretroviral therapy and 45.8% had advanced HIV disease. HIV and CE were diagnosed simultaneously in 29.6%.\n\nConclusion: HIV prevalence among patients with HCE was approximately four times the national prevalence (12.7%), suggesting an association between HIV and CE. The higher rate of seronegativity in patients living with HIV may have implications for CE diagnosis in high–HIV prevalence settings.",
  "abstract_shown": true,
  "affiliations": [
    "Surgical Gastroenterology Unit, Department of Surgery, University of Cape Town Health Sciences Faculty and Groote Schuur Hospital, Cape Town, South Africa",
    "Department of General Surgery, Section of Abdominal Transplant Surgery, Washington University St Louis, St. Louis, MO, USA",
    "Bioinformatics Unit, International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kate Couzens-Bohlin"
    },
    {
      "affs": [
        0
      ],
      "name": "Urda Kotze"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeandre Malherbe"
    },
    {
      "affs": [
        1
      ],
      "name": "Jessica Lindemann"
    },
    {
      "affs": [
        0
      ],
      "name": "Jake Krige"
    },
    {
      "affs": [
        0
      ],
      "name": "Christo Kloppers"
    },
    {
      "affs": [
        0
      ],
      "name": "Marc Bernon"
    },
    {
      "affs": [
        0
      ],
      "name": "Galya Chinnery"
    },
    {
      "affs": [
        2
      ],
      "name": "Stefano Cacciatore"
    },
    {
      "affs": [
        0
      ],
      "name": "Eduard Jonas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6stpzw038sj6r.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijregi.2026.101022",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725469/?tool=EBI",
  "id": "6stpzw038sj6r",
  "issns": [
    "2772-7076"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13725469",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Report"
    ],
    [
      "openalex",
      "2734|Parasitic infections in humans and animals"
    ]
  ],
  "openalex": "W7214079603",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725469/pdf/?tool=EBI",
  "pmcid": "PMC13725469",
  "pmid": "42974174",
  "published": "2026-09-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/6stpzw038sj6r.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13725469",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13725469"
    },
    {
      "first_seen": "2026-11-04T12:23:51Z",
      "native_id": "PMC13725469",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ijregi.2026.101022"
    },
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42974174",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974174"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Parasitic infections in humans and animals",
      "subfield": "general"
    }
  ],
  "title": "The clinical spectrum of hepatic cystic echinococcosis in a population with high human immunodeficiency virus prevalence: a retrospective cohort study in South Africa",
  "title_text": "The clinical spectrum of hepatic cystic echinococcosis in a population with high human immunodeficiency virus prevalence: a retrospective cohort study in South Africa",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:43Z",
  "url": "https://research.draconitic.com/paper/6stpzw038sj6r",
  "venue": "IJID regions",
  "versions": []
}