{
  "abstract": "Background Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a leading cause of endocarditis with poor outcomes. The magnitude and consistency of its mortality risk compared with methicillin-susceptible S. aureus (MSSA) remain uncertain. Methods Data were extracted from PubMed, Embase, Scopus, and Cochrane Library from database inception to 30 November 2025, without language restrictions. A random-effects model (Restricted Maximum-Likelihood) was used to calculate pooled risk ratios (RRs). Heterogeneity was explored by stratified and meta-regression analyses. Publication bias was assessed using funnel plot symmetry and Egger’s regression. Results Twenty-four studies, comprising 3291 patients (1,011 with MRSA and 2280 with MSSA), met the inclusion criteria. Pooled short-term mortality was significantly higher in MRSA endocarditis (30.9% vs 25.6%; RR 1.48, 95% CI 1.21-1.80; I² = 34%). Across stratified analyses by study design, setting, region, and study era, mortality remained consistently higher in MRSA endocarditis. No significant differences were found for heart failure (RR 1.08, 95% CI 0.90-1.30), embolic events (RR 0.82, 95% CI 0.51-1.33), stroke (RR 0.88, 95% CI 0.78-1.00), or surgery performed (RR 0.97, 95% CI 0.56-1.68) in MRSA and MSSA groups. No publication bias was revealed by Funnel-plot inspection and Egger’s test (p = 0.082). Meta-regression showed no effect modification by age, hospital-acquired infection, prosthetic valve, or right-sided endocarditis. Conclusions MRSA endocarditis carries a significantly higher short-term mortality than MSSA, consistent across study designs and study-level characteristics. The major complications were comparable between the two groups.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Infectious Diseases (Department of General Medicine), All India Institute of Medical Sciences"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Durga Shankar Meena"
    },
    {
      "affs": [
        0
      ],
      "name": "Deepak Kumar"
    },
    {
      "affs": [
        0
      ],
      "name": "Gopal Krishana Bohra"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6sv6684dp0vns.bib",
  "cited_by": 1,
  "doi": "10.1038/s43856-026-01746-9",
  "fulltext_url": "https://doi.org/10.1038/s43856-026-01746-9",
  "id": "6sv6684dp0vns",
  "issns": [
    "2730-664X"
  ],
  "landing_url": "https://doi.org/10.1038/s43856-026-01746-9",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2713|Infective Endocarditis Diagnosis and Management"
    ]
  ],
  "openalex": "W7166515125",
  "pdf_url": "https://www.nature.com/articles/s43856-026-01746-9_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/6sv6684dp0vns.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:19Z",
      "native_id": "2df08ee90d88434eba1d56e09b7f9bda",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s43856-026-01746-9"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Infective Endocarditis Diagnosis and Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Impact of methicillin resistance on mortality in Staphylococcus aureus endocarditis: a systematic review and meta-analysis",
  "title_text": "Impact of methicillin resistance on mortality in Staphylococcus aureus endocarditis: a systematic review and meta-analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:19Z",
  "url": "https://research.draconitic.com/paper/6sv6684dp0vns",
  "venue": "Communications Medicine",
  "versions": []
}