{
  "abstract": "The Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026(SSC 2026)represent a full systematic revision based on the 2021 iteration,encompassing 129 consensus statements in total,46 of which are newly added recommendations. While retaining the well-established core tenets of sepsis care,including early identification,timely and appropriate anti-infective administration,infection source control and organ function support,the updated guidelines have introduced targeted revisions across key domains:sepsis screening strategies,antimicrobial stewardship,fluid resuscitation regimens,vasoactive agent dosing,adjunctive interventions and post-sepsis long-term management. Rather than focusing solely on the adjustments to individual recommendations,the most notable paradigm shift embedded in this update lies in its refined clinical decision-making logic. Building on the existing standardized diagnosis and treatment framework,the guidelines explicitly place greater weight on integrating infection pre-test probability,baseline disease severity,real-time dynamic physiological trajectories and individual patient phenotypes into every stage of therapeutic decision-making. Over recent years,landmark large-scale randomized controlled trials including CLASSIC,CLOVERS,BLING Ⅲand ANDROMEDA-SHOCK-2 have continuously fueled the evolution of sepsis management,driving clinical practice away from one-size-fits-all protocols and uniform hemodynamic targets toward risk stratification,iterative dynamic assessment and phenotype-specific individualized interventions. This review contextualizes the core updates of SSC 2026 alongside latest high-level clinical evidence,focusing on four priority domains:early recognition and anti-infective optimization,hemodynamic resuscitation strategies,evidence-based adjunctive therapies and post-sepsis long-term care. Aligned with real-world clinical practice in China,the authors further elaborate on the realistic implementation foundation,clinical applicability boundaries and future research priorities for the ongoing transition of sepsis care from standardized population-based management to precision-guided therapy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "WANG Lei"
    },
    {
      "name": "GE Xin"
    },
    {
      "name": "ZHAO Mingyan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6t1707hrqha5t.bib",
  "cited_by": 0,
  "doi": "10.13429/j.cnki.cjcr.2026.10.001",
  "fulltext_url": "http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20261001",
  "id": "6t1707hrqha5t",
  "issns": [
    "1674-8182"
  ],
  "landing_url": "https://doi.org/10.13429/j.cnki.cjcr.2026.10.001",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7224128187",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "The Editorial Department of Chinese Journal of Clinical Research",
  "ris": "https://research.draconitic.com/paper/6t1707hrqha5t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:03Z",
      "native_id": "ca2542ade5604ea2a513496488ab82db",
      "source": "doaj",
      "url": "https://doi.org/10.13429/j.cnki.cjcr.2026.10.001"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Interpretation and insights into Surviving Sepsis Campaign:international guidelines for management of sepsis and septic shock 2026:transitioning from standardized management to precision-tailored therapy",
  "title_text": "Interpretation and insights into Surviving Sepsis Campaign:international guidelines for management of sepsis and septic shock 2026:transitioning from standardized management to precision-tailored therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:03Z",
  "url": "https://research.draconitic.com/paper/6t1707hrqha5t",
  "venue": "Zhongguo linchuang yanjiu",
  "versions": []
}