{
  "abstract": "This is a hypothesis-driven conceptual review, not a systematic review or meta-analysis, integrating two largely independent bodies of neuroscience literature — the neuroendocrinology of the menopause transition and the molecular synaptotoxicity of soluble amyloid-β (Aβ) oligomers — to ask whether they converge on a shared synaptic mechanism. Estrogen (17β-estradiol) and the neurosteroid allopregnanolone regulate hippocampal excitatory-inhibitory balance through ERβ, GPER1, and GABA-A δ-subunit-containing receptors, although not uniformly through “anti-LTD”: GPER1 mediates its own distinct form of long-term depression (LTD). Separately, soluble, preplaque Aβ oligomers facilitate NMDA receptor- and mGluR1-dependent hippocampal LTD via convergent calcineurin/AKAP150 spine elimination signaling, independent of amyloid plaques. We situate both literatures within Bienenstock–Cooper–Munro (BCM) metaplasticity theory, in which a sliding modification threshold, not a fixed switch, governs whether a synaptic input produces potentiation or depression. We propose a specific, falsifiable hypothesis: that decreasing estrogen/allopregnanolone tone and increasing proteoform burden act on convergent postsynaptic machinery to jointly lower this threshold in the hippocampal and limbic circuits. We explicitly distinguish this synaptic-level claim from the clinically separate phenomena of perimenopausal mood symptoms, subjective cognitive complaints, mild cognitive impairment, and Alzheimer's disease and weigh it against four competing models, including the possibility that endocrine decline and proteinopathy are both downstream of a shared upstream process. We present a structured, falsifiable research agenda specifying the experiments needed to confirm, partially confirm, or refute the proposed convergence. We do not claim that the central hypothesis is established; our contribution is to make an underexplored cross-disciplinary link explicit and testable.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Leon Sandler",
      "orcid": "0009-0007-4584-808X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6t5xbj7p9qbtm.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010677/v1",
  "fulltext_url": null,
  "id": "6t5xbj7p9qbtm",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010677/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Neuroscience and Neuropharmacology Research"
    ]
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  "openalex": "W7208835836",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010677/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-19",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/6t5xbj7p9qbtm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010677",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010677/v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Neuroscience and Neuropharmacology Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Does Endocrine State Gate Proteoform-Induced Synaptic Vulnerability? A Metaplasticity Framework for Menopause and Early Neurodegeneration",
  "title_text": "Does Endocrine State Gate Proteoform-Induced Synaptic Vulnerability? A Metaplasticity Framework for Menopause and Early Neurodegeneration",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/6t5xbj7p9qbtm",
  "venue": "ChemRxiv",
  "versions": []
}