{ "abstract": "Objective: Our objective was to evaluate the safety and effectiveness of Aquablation® as a salvage therapy in patients who underwent prior intervention for benign prostatic hyperplasia (BPH).\n\nMaterials and Methods: We retrospectively analysed 1887 consecutive men from the International Collaborative Aquablation Research Urology Society database between 2018 and 2024 who underwent Aquablation at one of four international centres. The cohort was divided into two groups based on the presence or absence of previous BPH intervention. Baseline characteristics, clinical and functional outcomes, and complication rates were compared between the two groups using analysis of variance and Kruskal–Wallis tests. Finally, exploratory sub‐analyses were performed in the salvage therapy group based on the type of prior BPH intervention.\n\nResults: Among the study population of 1887 men, 109 (5.8%) patients had undergone prior BPH intervention, and the remaining 1778 (94.2%) patients served as a control cohort. Prostate volumes were similar between both groups (82.3 vs 78.0 mL; P = 0.18). There were no significant differences in perioperative complications, 30‐day readmission rates, surgical retreatment rates, or sexual function outcome scores (all P > 0.05). There were also similar improvements in maximum urinary flow rates, post‐void residuals, International Prostate Symptom Scores, and quality of life scores (all P > 0.05). When comparing outcomes based on the type of prior BPH intervention, there were no differences in terms of operative time, prostate volumes, presence of median lobe, or complication rates.\n\nConclusion: We observed no statistically significant differences in safety or effectiveness for Aquablation as a salvage therapy for recurrent lower urinary tract symptoms after BPH intervention. Aquablation should be offered to men for whom prior procedures have failed and who want to preserve continence and sexual function.", "abstract_shown": true, "affiliations": [ "Faculty of Medicine University of Montreal Montreal QC Canada", "Division of Urology University of Montreal Montreal QC Canada", "Division of Urology McGill University Montreal QC Canada", "Faculty of Medicine McGill University Montreal QC Canada", "Faculty of Medicine University of Sherbrooke Sherbrooke QC Canada", "Division of Urology University of Vermont Medical Center Burlington VT USA", "Faculty of Medicine University of Laval Quebec City QC Canada", "Division of Urology University of Chicago Chicago IL USA", "Division of Urology Potomac Urology Center National Harbor MD USA", "Division of Urology NorthShore University Health System Evanston IL USA", "Division of Urology University Health Network Toronto ON Canada", "Urology Clinic Hospital Cruz Vermelha Lisbon Portugal", "Division of Urology BPH Canada Prostate Surgical Institute Montreal QC Canada" ], "article_type": "research article", "arxiv": null, "author_total": 25, "authors": [ { "affs": [ 0 ], "name": "Anouk Leathead", "orcid": "0009-0003-3761-492X" }, { "affs": [ 1 ], "name": "Nick Lee", "orcid": "0000-0002-7166-0503" }, { "affs": [ 2 ], "name": "Adel Arezki", "orcid": "0000-0002-9022-0677" }, { "affs": [ 2 ], "name": "David Bouhadana", "orcid": "0000-0003-3716-3447" }, { "affs": [ 3 ], "name": "Liam Murad", "orcid": "0000-0003-0760-3157" }, { "affs": [ 3 ], "name": "Tarek Benzouak", "orcid": "0000-0002-0310-2278" }, { "affs": [ 2 ], "name": "Iman Sadri", "orcid": "0000-0003-1399-7527" }, { "affs": [ 4 ], "name": "Rosie Foucault" }, { "affs": [ 2 ], "name": "Aalya Hamouda", "orcid": "0000-0003-4531-3943" }, { "affs": [ 5 ], "name": "Jeffrey Sioufi", "orcid": "0000-0003-0182-1663" }, { "affs": [ 6 ], "name": "Ilan Ohana", "orcid": "0009-0004-8580-686X" }, { "affs": [ 7 ], "name": "Joshua Cabral", "orcid": "0000-0002-1244-1415" }, { "affs": [ 7 ], "name": "Margaret Gannon" }, { "affs": [ 7 ], "name": "Gregory Raster", "orcid": "0009-0008-4059-0005" }, { "affs": [ 7 ], "name": "David Nusbaum" }, { "affs": [ 2 ], "name": "Abdulla Alameeri", "orcid": "0009-0000-2121-812X" }, { "affs": [ 8 ], "name": "John Klein" }, { "affs": [ 8 ], "name": "Inderjit Singh" }, { "affs": [ 9 ], "name": "James Kearns" }, { "affs": [ 8 ], "name": "Shawn Marhamati" }, { "affs": [ 9 ], "name": "Alexander Glaser", "orcid": "0000-0003-1781-9023" }, { "affs": [ 9 ], "name": "Brian Helfand" }, { "affs": [ 10 ], "name": "Dean Elterman" }, { "affs": [ 11 ], "name": "Tiago Rodrigues", "orcid": "0000-0001-9497-206X" }, { "affs": [ 12 ], "name": "Kevin C. Zorn" } ], "bibtex": "https://research.draconitic.com/paper/6tcv89k6cfg3m.bib", "cited_by": 0, "doi": "10.1111/bju.70481", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741102/", "id": "6tcv89k6cfg3m", "issns": [ "1464-4096", "1464-410X" ], "landing_url": "https://doi.org/10.1111/bju.70481", "language": "en", "licence": "CC-BY-NC-ND-4.0", "licence_label": "CC BY-NC-ND 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Original Article" ], [ "openalex", "2748|Urinary Bladder and Prostate Research" ] ], "openalex": "W7221030796", "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bju.70481", "pmcid": "PMC13741102", "pmid": "42843985", "published": "2026-10-07", "publisher": null, "ris": "https://research.draconitic.com/paper/6tcv89k6cfg3m.ris", "sources": [ { "first_seen": "2026-11-10T12:22:14Z", "native_id": "PMC13741102", "source": "pmc", "url": "https://doi.org/10.1111/bju.70481" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2748|Urinary Bladder and Prostate Research", "subfield": "general" } ], "title": "Aquablation as salvage therapy for benign prostatic hyperplasia: an international multicentre study", "title_text": "Aquablation as salvage therapy for benign prostatic hyperplasia: an international multicentre study", "type": "peer-reviewed", "updated_at": "2026-11-10T12:22:14Z", "url": "https://research.draconitic.com/paper/6tcv89k6cfg3m", "venue": "Bju International", "versions": [] }