{
  "abstract": "Electrochemical aptamer-based (E-AB) sensors are a major topic of research, yet their transition from laboratory proof-of-concept to robust real-life applications remains limited. This phenomenon can partly be explained by examining the fundamental physicochemical challenges at the bio-interface. This review provides a critical perspective on two decisive factors: interfacial functionalization and electrochemical interrogation. We argue that because E-AB performance is governed by electron transfer at the electrode-electrolyte boundary, the choice of immobilization chemistry is an important factor for analytical stability and sensitivity. Furthermore, we exemplify how different electrochemical techniques, ranging from square-wave voltammetry to impedimetric methods, impact electrode longevity and signal reliability. We believe the two aspects are the main contributing factors influencing the performance of E-AB sensors.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Teodora Lupoi"
    },
    {
      "name": "Yann R. Leroux"
    },
    {
      "name": "Florence Geneste"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6tkdzp2cb918m.bib",
  "cited_by": 0,
  "doi": "10.1016/j.coelec.2026.101933",
  "fulltext_url": null,
  "id": "6tkdzp2cb918m",
  "issns": [
    "2451-9103",
    "2451-9103"
  ],
  "landing_url": "https://hal.science/hal-05741463v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.chim.othe"
    ],
    [
      "hal",
      "1.sdv.ib"
    ],
    [
      "openalex",
      "1312|Advanced biosensing and bioanalysis techniques"
    ]
  ],
  "openalex": "W7204274955",
  "pdf_url": "https://hal.science/hal-05741463/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/6tkdzp2cb918m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "hal-05741463",
      "source": "hal",
      "url": "https://hal.science/hal-05741463v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ib",
      "subfield": "systems-synthetic"
    },
    {
      "field": "chemistry",
      "origin": "hal:0.chim",
      "subfield": "general"
    }
  ],
  "title": "The influence of surface functionalization and signal transduction on electrochemical aptamer-based sensors",
  "title_text": "The influence of surface functionalization and signal transduction on electrochemical aptamer-based sensors",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/6tkdzp2cb918m",
  "venue": "Current Opinion in Electrochemistry",
  "versions": []
}