{
  "abstract": "Rationale: Biologic therapies are an increasingly important treatment option for atopic diseases, which commonly affect women of reproductive age. However, global barriers to prescribing biologic therapies to pregnant patients remain poorly understood. Methods: The World Allergy Organization (WAO) Junior Members Steering Group conducted a global, web-based survey of healthcare professionals to evaluate prescribing patterns and barriers to the use of biologic therapies for atopic diseases during pregnancy. Results: From 322 total participants representing 71 countries, 77 of 314 (24.5%) reported prescribing biologic therapies for atopic diseases during pregnancy. The most frequently prescribed biologic therapies during pregnancy were omalizumab (79.2%) and dupilumab (32.5%), followed by benralizumab (7.8%), mepolizumab (7.8%), tralokinumab (3.9%), tezepelumab (2.6%), and reslizumab (1.3%). Twenty-three respondents encountered barriers to prescribing biologic therapies to pregnant patients, including patients’ concerns about the impact on pregnancy (82.6%), adverse reactions (47.8%), difficulty securing insurance coverage (13.0%), and high patient costs (8.7%). Reported biologic therapies discontinued due to pregnancy included dupilumab (39.1%), mepolizumab (26.1%), omalizumab (26.1%), and benralizumab (13.0%). Twelve of the 23 healthcare professionals who discontinued biologic therapies reported that their pregnant patients experienced worsening symptoms after stopping. Seven respondents (9.9%) reported adverse maternal or fetal outcomes in pregnant patients receiving biologic treatment for atopic diseases, including allergic/immune disorders (3), congenital defects (2), miscarriage (1), and preeclampsia (1). Only 42.3% of respondents who prescribed biologics to pregnant patients reported enrolling these patients in a pregnancy registry. Conclusions: Significant barriers limit the prescriptions of biologic therapies for atopic diseases during pregnancy. Multidisciplinary collaboration among clinicians, researchers, and the pharmaceutical industry is essential for developing strategies to overcome these barriers and improve access to biologic therapy for pregnant patients.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Mayo Clinic, Rochester, MN, USA; Corresponding author. Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.",
    "Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Mayo Clinic, Rochester, MN, USA",
    "Mayo Clinic, Division of Biomedical Statistics and Informatics, Rochester, MN, USA",
    "Department of Internal Medicine, University of Arizona, Phoenix, AZ, USA",
    "Division of Pulmonary, Allergy, and Sleep Medicine, Mayo Clinic, Jacksonville, FL, USA",
    "Division of Allergy and Immunology, University of South Florida, Tampa, FL, USA",
    "Division of Allergy, Clinical Immunology and Rheumatology, University of Kansas, Kansas City, KS, USA",
    "Allergy Center, CUF Descobertas Hospital and CUF Tejo Hospital, Lisbon, Portugal; National School of Public Health, NOVA University of Lisbon, Lisbon, Portugal; Institut Desbrest d’Epidémiologie et de Santé Publique, University of Montpellier, Montpellier, France",
    "Hospital Universitario HLA Inmaculada Granada, Spain",
    "School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam",
    "Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China",
    "Department of Paediatrics and Paediatric Infectious Diseases, Sechenov University, Moscow, Russia",
    "Division of Allergy and Immunology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada",
    "Department of Allergy, Guthrie Medical Group Sayre, Pennsylvania, USA",
    "Department of Adult Clinical Immunology and Allergic Diseases, Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye",
    "Allergy Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa",
    "Oncology Service, University Hospital Dr. José Eleuterio González, Autonomous University of Nuevo León Monterrey, Nuevo León, México",
    "Population Allergy, Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, 3010, Australia; Deakin Lifespan Institute, School of Psychology, Deakin University Geelong, Victoria, Australia",
    "University of Florida Gainesville, FL, USA",
    "Allergy Unit and Asthma Center, Verona Integrated University Hospital and Department of Medicine, University of Verona, Verona, Italy",
    "Department of Dermatology and Venereology, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria",
    "Division of Allergy, Asthma and Clinical Immunology, Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA",
    "University Hospital Dr Dragisa Misovic Belgrade, Serbia",
    "Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam",
    "Division of Allergy, Department of Pulmonology, University Hospital of Montpellier, France; Desbrest Institute of Epidemiology and Public Health, University of Montpellier - INSERM, Montpellier, France; WHO Collaborating Centre on Scientific Classification Support, Montpellier, France"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sergio E. Chiarella, MD"
    },
    {
      "affs": [
        1
      ],
      "name": "Isabella Novoa-Caicedo, MD"
    },
    {
      "affs": [
        2
      ],
      "name": "Sara M. Jenkins, MS"
    },
    {
      "affs": [
        3
      ],
      "name": "Divya Shah, MD"
    },
    {
      "affs": [
        3
      ],
      "name": "Ishitha Jagadish, MD"
    },
    {
      "affs": [
        4
      ],
      "name": "Leah Ishmael, DO"
    },
    {
      "affs": [
        5
      ],
      "name": "Fnu Shakuntulla, MD"
    },
    {
      "affs": [
        6
      ],
      "name": "Andrea Sitek, MD"
    },
    {
      "affs": [
        7
      ],
      "name": "Barbara Kong-Cardoso, MD"
    },
    {
      "affs": [
        8
      ],
      "name": "Isabel Fernandez de Alba, MD"
    },
    {
      "affs": [
        9
      ],
      "name": "Duy Le Pham, MD, PhD"
    },
    {
      "affs": [
        10
      ],
      "name": "Agnes Sze-yin Leung, MBChB"
    },
    {
      "affs": [
        11
      ],
      "name": "Daria Levina, MD, MSc"
    },
    {
      "affs": [
        12
      ],
      "name": "Shun Chi Ryan Lo, MD"
    },
    {
      "affs": [
        13
      ],
      "name": "Matthew Norris, MD"
    },
    {
      "affs": [
        14
      ],
      "name": "Nida Öztop, MD"
    },
    {
      "affs": [
        15
      ],
      "name": "Thulja Trikamjee, MD"
    },
    {
      "affs": [
        16
      ],
      "name": "Rosalaura Villarreal-Gonzalez, MD, PhD"
    },
    {
      "affs": [
        17
      ],
      "name": "Yichao Wang, MD, PhD"
    },
    {
      "affs": [
        18
      ],
      "name": "Lyda Cuervo-Pardo, MD"
    },
    {
      "affs": [
        19
      ],
      "name": "Marco Caminati, MD"
    },
    {
      "affs": [
        20
      ],
      "name": "Razvigor Darlenski, MD, PhD"
    },
    {
      "affs": [
        21
      ],
      "name": "Alexei Gonzalez-Estrada, MD"
    },
    {
      "affs": [
        22
      ],
      "name": "Ivana Filipovic, MD, PhD"
    },
    {
      "affs": [
        23
      ],
      "name": "Tu HK. Trinh, MD, PhD"
    },
    {
      "affs": [
        24
      ],
      "name": "Luciana Kase Tanno, MD, PhD"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6vr1yb0r6cxfj.bib",
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  "doi": "10.1016/j.waojou.2026.101485",
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  "published": "2026-11-05",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/6vr1yb0r6cxfj.ris",
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  "title": "Biologic therapies for atopic diseases during pregnancy: A World Allergy Organization survey",
  "title_text": "Biologic therapies for atopic diseases during pregnancy: A World Allergy Organization survey",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T14:20:33Z",
  "url": "https://research.draconitic.com/paper/6vr1yb0r6cxfj",
  "venue": "World Allergy Organization Journal",
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}