{
  "abstract": "Purpose\n\nThis study aimed to explore the occurrence, identify independent predictors, and assess the clinical implications of END following EVT in individuals with acute LVO.Methods\n\nParticipants were enrolled from the ANGEL-ACT registry. END was characterized by a rise of ≥ 4 points in the National Institutes of Health Stroke Scale (NIHSS) score from baseline to 24 h post-EVT. We conducted logistic regression analyses to pinpoint independent predictors of END.Results\n\nAmong the 1557 patients included in the study, the occurrence of END stood at 9.8%. Factors independently associated with END included an admission NIHSS (adjusted odds ratio (aOR) = 4.067, 95% CI 2.513 to 6.582, p < 0.0001), an admission neutrophil-to-lymphocyte ratio (NLR) exceeding 5 (aOR = 1.811, 95% CI 1.246 to 2.632, p = 0.0018), the use of general anesthesia (GA) (aOR = 0.474, 95% CI 0.330 to 0.682, p < 0.0001), longer procedure duration (aOR = 5.500, 95% CI 1.45 to 20.871, p = 0.0122), and more than three retrieval attempts (aOR = 1.294, 95% CI 1.177 to 1.422, p < 0.0001).Conclusions\n\nEND manifested in 9.8% of patients undergoing endovascular therapy (EVT) for acute large vessel occlusion (LVO). This investigation highlights various independent predictors of END, providing valuable insights for daily clinical practice aimed at enhancing the effectiveness of intravascular thrombectomy.Registration\n\nURL: https://www.Clinicaltrials\n\ngov ; Unique identifier: NCT03370939; registration date: 11th November 2017.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Shanxi Key Laboratory of Brain Disease Control, Shanxi Provincial People's Hospital, Taiyuan, China.",
    "Department of Neuroscience, Dharmais Cancer Hospital - National Cancer Center, Jakarta, Indonesia.",
    "Clinical Research Unit, Dharmais Cancer Hospital - National Cancer Center, Jakarta, Indonesia.",
    "Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No.119, the South Fourth Ring West Road, Fengtai District, Beijing, 100050, China.",
    "Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.",
    "National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.",
    "Department of Neurology, Shanxi Key Laboratory of Brain Disease Control, Shanxi Provincial People's Hospital, Taiyuan, China. yaxuansjjr@163.com.",
    "Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No.119, the South Fourth Ring West Road, Fengtai District, Beijing, 100050, China. doctorzhongrongm@126.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bin Han"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Raynald"
    },
    {
      "affs": [
        1
      ],
      "name": "Muhammad Firdaus"
    },
    {
      "affs": [
        3
      ],
      "name": "Dapeng Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaxin Wu"
    },
    {
      "affs": [
        3
      ],
      "name": "XuTong"
    },
    {
      "affs": [
        3
      ],
      "name": "Baixue Jia"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Anxin Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Dapeng Mo"
    },
    {
      "affs": [
        3
      ],
      "name": "Feng Gao"
    },
    {
      "affs": [
        3
      ],
      "name": "Ning Ma"
    },
    {
      "affs": [
        6
      ],
      "name": "Yaxuan Sun"
    },
    {
      "affs": [
        7
      ],
      "name": "Zhongrong Miao",
      "orcid": "0009-0008-9515-2184"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6vsm123a5r04r.bib",
  "cited_by": 0,
  "doi": "10.1186/s12883-026-05150-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13700224",
  "id": "6vsm123a5r04r",
  "issns": [
    "1471-2377"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928143",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7171680141",
  "pdf_url": "https://europepmc.org/articles/PMC13700224?pdf=render",
  "pmcid": "PMC13700224",
  "pmid": "42928143",
  "published": "2026-07-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6vsm123a5r04r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:20Z",
      "native_id": "MED:42928143",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928143"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Early neurological deterioration after endovascular treatment in acute ischemic stroke with large vessel occlusion.",
  "title_text": "Early neurological deterioration after endovascular treatment in acute ischemic stroke with large vessel occlusion.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:20Z",
  "url": "https://research.draconitic.com/paper/6vsm123a5r04r",
  "venue": "BMC neurology",
  "versions": []
}