{
  "abstract": "Lipid phosphate phosphatases are a family of enzymes with diverse cellular metabolic functions. Phospholipid phosphatase 6 (PLPP6) is a regulator of cellular polyisoprenyl phosphates; however, its in vivo functions remain to be determined. Here, mouse PLPP6 was characterized to possess similar catalytic properties as the human enzyme. Plpp6 knockout mice ( Plpp6 −/− ) were generated and displayed decreased airway allergen sensitization, pointing to a role for PLPP6 in the early events of lung allergic responses. Dendritic cell (DC) responses were investigated and endocytosis of allergen via macropinocytosis was decreased in Plpp6 −/− DCs that had lower cholesterol content. When reversed by cholesterol loading, the DC macropinocytosis defect is corrected. Adoptive transfer of Plpp6 −/− DCs to wild-type mice during sensitization was sufficient to decrease allergen-induced responses . Together, our findings have identified PLPP6 as a pivotal regulator of DC cholesterol content and macropinocytosis, cellular mechanisms that are important for pathologic responses in allergen-induced lung inflammation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Thayse Brüggemann"
    },
    {
      "name": "Troy Carlo"
    },
    {
      "name": "Nandini Krishnamoorthy"
    },
    {
      "name": "Melody Duvall"
    },
    {
      "name": "Raja-Elie Abdulnour"
    },
    {
      "name": "Julie Nijmeh"
    },
    {
      "name": "Hong Yong Peh"
    },
    {
      "name": "Harilaos Filippakis"
    },
    {
      "name": "Roxanne Croze"
    },
    {
      "name": "Byoungsook Goh"
    },
    {
      "name": "Sungwhan Oh"
    },
    {
      "name": "Bruce Levy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6vt5tgax0bw4m.bib",
  "cited_by": 5,
  "doi": "10.1016/j.isci.2022.105185",
  "fulltext_url": null,
  "id": "6vt5tgax0bw4m",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://hal.science/hal-05787787v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W4296892976",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Cell Press, Elsevier [2018-....]",
  "ris": "https://research.draconitic.com/paper/6vt5tgax0bw4m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:51Z",
      "native_id": "hal-05787787",
      "source": "hal",
      "url": "https://hal.science/hal-05787787v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization",
  "title_text": "Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:51Z",
  "url": "https://research.draconitic.com/paper/6vt5tgax0bw4m",
  "venue": "iScience",
  "versions": []
}