{
  "abstract": "Human leukocyte antigen (HLA) associations anchor genetic susceptibility to autoimmune hepatitis (AIH). Connecting this susceptibility to the immune reactions that sustain liver injury remains a central challenge. Recent antigen-specific experiments and tissue analyses provide complementary insights into recognition and injury. This Mini Review examines how population-specific HLA associations, SepSecS-reactive lymphocytes and intrahepatic immune states inform the relationship between antigen recognition and inflammatory amplification. The evidence reveals three unresolved relationships between susceptibility, recognition and injury. Class II-restricted autoreactivity and conditionally independent class I associations in Han Chinese AIH implicate potentially complementary immune pathways. Antigen-specific T-cell responses extend beyond the boundaries defined by autoantibody status. Receptor specificity and the capacity to sustain tissue injury require distinct functional tests. We evaluate antigen-presentation experiments, receptor studies and tissue profiling, distinguishing human observations from mechanistic models. The synthesis supports a model in which heterogeneous antigen-specific responses may converge on shared inflammatory processes. Priorities include linking genetic risk to natural antigen presentation and defining autoreactive clone function in liver tissue. Matched perturbation experiments should then test antigen dependence alongside cytokine-dependent injury. Resolving these questions would clarify which mechanisms require antigen-specific intervention and which reflect downstream inflammatory amplification.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chinese Medicine, Hubei University of Chinese Medicine",
    "Institute of Liver Diseases, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine",
    "Hubei Provincial Clinical Research Center of Traditional Chinese Medicine for Liver Diseases",
    "Hubei Shizhen Laboratory",
    "Affiliated Hospital of Hubei University of Chinese Medicine"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zihao Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yifan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Haoyang Zou"
    },
    {
      "affs": [
        1,
        2,
        3,
        4
      ],
      "name": "Sheng Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6w33mhv8nxak0.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1996626",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725687/?tool=EBI",
  "id": "6w33mhv8nxak0",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1996626/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Mini Review"
    ],
    [
      "openalex",
      "2721|Liver Diseases and Immunity"
    ]
  ],
  "openalex": "W7222934992",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1996626/pdf",
  "pmcid": "PMC13725687",
  "pmid": "42974240",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6w33mhv8nxak0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1996626",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1996626/full"
    },
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13725687",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13725687"
    },
    {
      "first_seen": "2026-11-04T12:23:59Z",
      "native_id": "PMC13725687",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1996626"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42974240",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974240"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Antigen specificity and inflammatory amplification in autoimmune hepatitis",
  "title_text": "Antigen specificity and inflammatory amplification in autoimmune hepatitis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:22:11Z",
  "url": "https://research.draconitic.com/paper/6w33mhv8nxak0",
  "venue": "Frontiers in Immunology",
  "versions": []
}