{
  "abstract": "Background/Objectives: The role of induction chemotherapy (IC) in advanced oral cavity squamous cell carcinoma (OCSCC) remains controversial. This study evaluated patient-level changes in primary-tumour and cervical nodal dimensions, subsequent definitive treatment, and survival after curative-intent IC. Methods: We retrospectively analysed 38 patients with primary, non-metastatic OCSCC treated with curative-intent IC between 2009 and 2024. Recurrent disease, second primary tumours, non-squamous histology, non-oral primary sites, baseline metastatic disease, direct chemoradiotherapy, and palliative systemic treatment were excluded. A prespecified simplified unidimensional radiological analysis was performed. The maximum axial primary-tumour diameter, the largest baseline cervical node, and total recorded nodal burden were compared before and after IC. Baseline nodes absent after IC were coded as 0 mm only when disappearance was confirmed on post-IC anatomical imaging. The overall survival (OS) was measured from IC initiation. Results: Primary-tumour measurements were evaluable in 25 patients. Median diameter decreased from 55.0 to 46.0 mm, corresponding to a median change of −13.5% (p = 0.049). The largest baseline node was evaluable in 19 patients and decreased from 17.0 to 13.0 mm, a median change of −16.7% (p = 0.004). Total nodal burden changed by a median of −8.3% (p = 0.257). Primary-tumour change did not differ significantly from largest-node change (p = 0.073) or total nodal-burden change (p = 0.860). TP and TPF showed no difference in primary-tumour change (p = 0.954). During a median follow-up of 40.4 months, 16 patients died. Median OS was 45.1 months and 5-year OS was 35.6%. Conclusions: IC produced heterogeneous, generally modest radiological changes. The largest baseline node decreased significantly, whereas total nodal burden did not. These data do not establish the superiority of one regimen or a causal survival benefit from surgery and should be considered hypothesis-generating.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Linkou 333423, Taiwan",
    "Maxillofacial Surgery Unit, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy",
    "Department of Medical Education, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan",
    "Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial, Linkou 333423, Taiwan",
    "School of Medicine, Medical College, Chang Gung University, Kwei-Shan, Taoyuan 333323, Taiwan",
    "Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Keelung Branch, Keelung 204201, Taiwan",
    "Department of Otolaryngology, Hsin-Chu MacKay Memorial Hospital, Hsin-Chu 300044, Taiwan",
    "Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan",
    "Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333002, Taiwan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Paola Lovino Camerino"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "I-Ching Chen"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Cheng-Lung Hsu"
    },
    {
      "affs": [
        0,
        4,
        5
      ],
      "name": "Chi-Kuang Young"
    },
    {
      "affs": [
        6
      ],
      "name": "Chih-Yung Yang"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Yu-Feng Hu"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Hung-Ming Wang",
      "orcid": "0000-0003-0066-829X"
    },
    {
      "affs": [
        0
      ],
      "name": "Valentina Campagnari",
      "orcid": "0009-0008-8311-2732"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Chun-Ta Liao"
    },
    {
      "affs": [
        4,
        7
      ],
      "name": "Chung-Kan Tsao"
    },
    {
      "affs": [
        0,
        4,
        8
      ],
      "name": "Shiang-Fu Huang",
      "orcid": "0000-0003-3582-9938"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6w79y0r4fp3za.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15208165",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706574/?tool=EBI",
  "id": "6w79y0r4fp3za",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/8165",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7223034475",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706574/pdf/?tool=EBI",
  "pmcid": "PMC13706574",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/6w79y0r4fp3za.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15208165",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/8165"
    },
    {
      "first_seen": "2026-10-30T12:21:45Z",
      "native_id": "PMC:PMC13706574",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706574"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "Clinical and Radiological Outcomes After Curative-Intent Induction Chemotherapy for Primary Advanced Oral Cavity Squamous Cell Carcinoma",
  "title_text": "Clinical and Radiological Outcomes After Curative-Intent Induction Chemotherapy for Primary Advanced Oral Cavity Squamous Cell Carcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:45Z",
  "url": "https://research.draconitic.com/paper/6w79y0r4fp3za",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}