{
  "abstract": "Hypoxia-powered blood oxygen level-dependent (BOLD) MRI probes the BOLD response to a controlled transient hypoxic stimulus. We developed GLIODISSECT, an operational voxel-wise framework that separates relative response arrival, descending and recovery transitions, and threshold-defined steady state amplitude. Twenty healthy controls underwent 3-T BOLD MRI during a double hypoxic-step challenge, and three patients with newly diagnosed glioblastoma were included as proof-of-concept cases. Full-record cross-correlation and first-step 10% landmarks yielded one refined voxel-wise lag that was reused downstream. Alternative 5%/95% and 20%/80% thresholds preserved steady state map patterns (median within-subject spatial r 0.9987-0.9998), while timing measures were more threshold-dependent. Numerical criteria were satisfied in 97.789% and 97.682% of evaluable delay-to-plateau (DTP) estimates and in all evaluable delay-to-return (DTR) estimates. Leave-one-subject-out validation of the global-response-adjusted steady state model yielded a median voxel-wise Q2 of 0.345 and reduced pooled prediction error by 16.0%, improving 19 of 20 controls. In the three illustrative cases, component and deviation maps displayed spatially heterogeneous timing and steady state patterns that could not be represented by one response-amplitude summary. GLIODISSECT supports component-specific mapping and voxel-wise normative interpretation. Biological and clinical validation remain required.",
  "abstract_shown": true,
  "affiliations": [
    "University Hospital Zurich: UniversitatsSpital Zurich"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "T. Schmidlechner"
    },
    {
      "name": "V. Stumpo"
    },
    {
      "name": "E. Jehli"
    },
    {
      "name": "L. Zerweck"
    },
    {
      "name": "J. Bellomo"
    },
    {
      "name": "M. Gönel"
    },
    {
      "name": "F. Müller"
    },
    {
      "name": "N. Cantavella Franch"
    },
    {
      "name": "M. Sebök"
    },
    {
      "name": "A. Bink"
    },
    {
      "name": "Z. Kulcsar"
    },
    {
      "name": "M. Weller"
    },
    {
      "name": "L. Regli"
    },
    {
      "name": "J. Fierstra"
    },
    {
      "name": "C. H. B. van Niftrik"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6whqqh3prg8pf.bib",
  "cited_by": 1,
  "doi": "10.64898/2026.05.27.26354265",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.05.27.26354265v2.full",
  "id": "6whqqh3prg8pf",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.05.27.26354265v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "radiology and imaging"
    ],
    [
      "openalex",
      "2741|Advanced MRI Techniques and Applications"
    ]
  ],
  "openalex": "W7162812704",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.05.27.26354265v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6whqqh3prg8pf.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:43Z",
      "native_id": "10.64898/2026.05.27.26354265",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.05.27.26354265v2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:radiology and imaging",
      "subfield": "imaging"
    }
  ],
  "title": "Voxel-wise temporal decomposition of hypoxia-powered BOLD MRI: method development and proof-of-concept application in glioblastoma",
  "title_text": "Voxel-wise temporal decomposition of hypoxia-powered BOLD MRI: method development and proof-of-concept application in glioblastoma",
  "type": "preprint",
  "updated_at": "2026-11-01T00:20:31Z",
  "url": "https://research.draconitic.com/paper/6whqqh3prg8pf",
  "venue": "medRxiv",
  "versions": []
}