{
  "abstract": "The body plan of multicellular animals is here revisited as the program of construction, contained in the zygote as a self-extracting archive -and later borne in all nucleated cells of any given multicellular animal -which is launched at fecundation. It unfolds in embryogenesis by a succession of differentiation branchings in the cellular matter produced by successive cell proliferations, leading to the different cell types a multicellular organism -in its achieved form -is made of, 20 for sponges (Porifera), 200 to 400 for Humans. The body plan, once has been physically achieved as coherent and viable the animal multicellular organism for which it is designed, must be maintained in the different constituting tissues and organs of the organism by local cohesion control mechanisms. Some of them might be linked to the permanent action of tissue resident macrophages, already present from early embryogenesis in each tissue of the organism. Cancer is a disease of animal multicellular organisms only, and its beginning always occurs in a given tissue, in which some such cohesion controls fail, on differentiation and on proliferation. This essay * theoretically investigates possible control mechanisms of tissue cohesion maintenance failed in cancer, attempting in particular at eliciting a role for resident macrophages in such local tissue maintenance.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "Jean Clairambault"
    },
    {
      "name": "Lia Sela"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6wj25sja5kr6b.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": null,
  "id": "6wj25sja5kr6b",
  "issns": [],
  "landing_url": "https://inria.hal.science/hal-05690244v2",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.math"
    ],
    [
      "hal",
      "0.sdv"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://inria.hal.science/hal-05690244/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6wj25sja5kr6b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:01Z",
      "native_id": "hal-05690244",
      "source": "hal",
      "url": "https://inria.hal.science/hal-05690244v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "mathematics",
      "origin": "hal:0.math",
      "subfield": "general"
    }
  ],
  "title": "The animal body plan revisited in light of the failure of local tissue cohesion in cancer",
  "title_text": "The animal body plan revisited in light of the failure of local tissue cohesion in cancer",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:01Z",
  "url": "https://research.draconitic.com/paper/6wj25sja5kr6b",
  "venue": "HAL",
  "versions": []
}