{
  "abstract": "The apolipoprotein E (APOE) haplotypes are known to be associated with dementia, with the ε4 haplotype associated with higher risk. It has been suggested that the APOE ε2 allele serves as a protective factor for dementia. However, data on the effects of the homozygous APOE ε2/ε2 genotype are limited, likely due to the rarity of the APOE ε2/ε2 genotype. Furthermore, the association between APOE genotypes and dementia may differ across self-reported race. We aim to investigate the association between APOE genotypes and dementia overall and across self-reported race, with a focus on the potential protective effects of the ε2 haplotype and differences across race.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 36,
  "authors": [
    {
      "name": "Timothy M. Hughes"
    },
    {
      "name": "Vilmundur Guðnason"
    },
    {
      "name": "Michael Griswold"
    },
    {
      "name": "Paul S. De Vries"
    },
    {
      "name": "Alison Fohner"
    },
    {
      "name": "Pamela L. Lutsey"
    },
    {
      "name": "Rachel Zmora"
    },
    {
      "name": "Elizabeth A. Peterson"
    },
    {
      "name": "Denise Scholtens"
    },
    {
      "name": "Norrina B. Allen"
    },
    {
      "name": "Sanaz Sedaghat"
    },
    {
      "name": "Natalia Lakomski"
    },
    {
      "name": "Katherine Giorgio"
    },
    {
      "name": "John Stephen"
    },
    {
      "name": "Maxwell Mansolf"
    },
    {
      "name": "Aïcha Soumaré"
    },
    {
      "name": "Alden L. Gross"
    },
    {
      "name": "Allison E. Aiello"
    },
    {
      "name": "Archana Singh-Manoux"
    },
    {
      "name": "M. Arfan Ikram"
    },
    {
      "name": "Catherine Helmer"
    },
    {
      "name": "Claudia L. Satizabal"
    },
    {
      "name": "Deborah A. Levine"
    },
    {
      "name": "Donald M. Lloyd-Jones"
    },
    {
      "name": "Emily M. Briceño"
    },
    {
      "name": "Farzaneh A. Sorond"
    },
    {
      "name": "Frank J. Wolters"
    },
    {
      "name": "Jayandra J. Himali"
    },
    {
      "name": "Lenore J. Launer"
    },
    {
      "name": "Djass Mbangdadji"
    },
    {
      "name": "David Li"
    },
    {
      "name": "Lihui Zhao"
    },
    {
      "name": "Oscar L. Lopez"
    },
    {
      "name": "Stéphanie Debette"
    },
    {
      "name": "Sudha Seshadri"
    },
    {
      "name": "Suzanne E. Judd"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6wpdw9tv21mh1.bib",
  "cited_by": 0,
  "doi": "10.1212/nxg.0000000000200417",
  "fulltext_url": null,
  "id": "6wpdw9tv21mh1",
  "issns": [
    "2376-7839"
  ],
  "landing_url": "https://hal.science/hal-05736253v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7168519743",
  "pdf_url": "https://www.neurology.org/doi/pdf/10.1212/NXG.0000000000200417",
  "pmcid": null,
  "pmid": "42519715",
  "published": "2026-09-02",
  "publisher": "American Academy of Neurology",
  "ris": "https://research.draconitic.com/paper/6wpdw9tv21mh1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:27Z",
      "native_id": "hal-05736253",
      "source": "hal",
      "url": "https://hal.science/hal-05736253v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "The Association Between APOE Genotype, Race, and Dementia: An Analysis of 7 Population-Based Cohort Studies",
  "title_text": "The Association Between APOE Genotype, Race, and Dementia: An Analysis of 7 Population-Based Cohort Studies",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:27Z",
  "url": "https://research.draconitic.com/paper/6wpdw9tv21mh1",
  "venue": "Neurology Genetics",
  "versions": []
}