{
  "abstract": "Fundic gland polyps (FGPs) may enlarge during long-term proton pump inhibitor (PPI) therapy, potentially in association with acid suppression and hypergastrinemia. Potassium-competitive acid blockers (PCABs) provide potent and sustained acid suppression and may induce comparable or greater elevations in serum gastrin levels than PPIs. We report a case of FGPs in which regression was documented after changes in acid-suppressive therapy, with no subsequent re-enlargement during long-term use of PCABs. A woman in her 60s with gastroesophageal reflux disease developed progressive enlargement of FGPs during 7 years of rabeprazole therapy. Rabeprazole was discontinued because of marked redness of the enlarged FGPs and concern for possible bleeding and was replaced with an H2-receptor antagonist. After reintroduction of rabeprazole, treatment was switched to a PCAB because of insufficient symptom control. Four months after PCAB initiation, esophagogastroduodenoscopy demonstrated marked regression of the FGPs, with no subsequent re-enlargement during continued PCAB therapy. Serum gastrin levels were elevated at both measurements during PCAB use (491.9 and 753.7 pg/mL). Histological examination revealed similar fundic gland changes characteristic of FGPs in both a residual polyp and the endoscopically non-polypoid background mucosa, without dysplasia. Because the exact timing of FGP regression could not be determined, the regression observed 4 months after vonoprazan initiation cannot be solely attributed to vonoprazan therapy and may have occurred, at least in part, during the preceding period of PPI discontinuation. Nevertheless, no subsequent re-enlargement was observed during long-term vonoprazan therapy. Clinical Trial Registration: Clinical trial registration was not applicable because this was a single case report.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Digestive Endoscopy Tokyo Women's Medical University Hospital Tokyo Japan.",
    "Department of Gastroenterology Ina Hospital Saitama Japan.",
    "Department of Pathology Dokkyo Medical University Saitama Medical Center Saitama Japan."
  ],
  "article_type": "case study",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yoshitsugu Misumi"
    },
    {
      "affs": [
        1
      ],
      "name": "Tatsuyuki Marumo"
    },
    {
      "affs": [
        2
      ],
      "name": "Shinichi Ban"
    },
    {
      "affs": [
        0
      ],
      "name": "Kouichi Nonaka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6wzvnxx3rpw2x.bib",
  "cited_by": 0,
  "doi": "10.1002/deo2.70463",
  "fulltext_url": "https://europepmc.org/articles/PMC13723742",
  "id": "6wzvnxx3rpw2x",
  "issns": [
    "2692-4609"
  ],
  "landing_url": "https://europepmc.org/article/MED/42968916",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2715|Gastroesophageal reflux and treatments"
    ]
  ],
  "openalex": "W7225047589",
  "pdf_url": "https://europepmc.org/articles/PMC13723742?pdf=render",
  "pmcid": "PMC13723742",
  "pmid": "42968916",
  "published": "2026-11-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/6wzvnxx3rpw2x.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42968916",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42968916"
    },
    {
      "first_seen": "2026-11-04T12:22:19Z",
      "native_id": "PMC13723742",
      "source": "pmc",
      "url": "https://doi.org/10.1002/deo2.70463"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Gastroesophageal reflux and treatments",
      "subfield": "general"
    }
  ],
  "title": "Reconsidering the Mechanism of Proton Pump Inhibitor-Associated Fundic Gland Polyps: Absence of Re-enlargement during Potassium-Competitive Acid Blocker Therapy.",
  "title_text": "Reconsidering the Mechanism of Proton Pump Inhibitor-Associated Fundic Gland Polyps: Absence of Re-enlargement during Potassium-Competitive Acid Blocker Therapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:30Z",
  "url": "https://research.draconitic.com/paper/6wzvnxx3rpw2x",
  "venue": "DEN open",
  "versions": []
}