{
  "abstract": "Patients with coexisting carotid and coronary artery disease face a complex surgical decision regarding whether to undergo coronary artery bypass grafting (CABG) alone or combined with carotid endarterectomy (CEA). Evidence remains conflicting, with some studies suggesting stroke reduction from a combined approach while others report increased perioperative morbidity without a survival advantage, contributing to weak ACCF/AHA and ESC/EACTS guideline recommendations. We conducted a systematic review and meta-analysis of randomised controlled trials and propensity-matched studies comparing CABG alone versus CABG+CEA. Five studies involving 23,916 patients were included, of whom 29% underwent combined surgery. CABG+CEA was associated with a significantly higher incidence of perioperative stroke (OR 1.5; 95% CI 1.1-2.0; P=0.03), but no significant differences were observed in 30-day mortality, major adverse cardiovascular events, myocardial infarction, or hospital length of stay. These findings indicate that adding CEA to CABG increases stroke risk without providing a clear survival benefit, supporting guideline recommendations for a selective, risk-based strategy. Until higher-quality evidence becomes available, concurrent CEA+CABG should be reserved for carefully selected patients in whom the anticipated benefits outweigh potential harms.",
  "abstract_shown": true,
  "affiliations": [
    "New Vision University School of Medicine, Tbilisi, Georgia.",
    "Medisch Spectrum Enschede, Enschede, Netherlands.",
    "Pontifical Catholic University of Paraná, Curitiba, Brazil.",
    "Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Rabat, Morocco.",
    "Center for Translational Research and Systems Medicine, \"Victor Babeș\" University of Medicine and Pharmacy of Timișoara, Romania."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kristine Santos",
      "orcid": "0009-0004-3563-4211"
    },
    {
      "affs": [
        2
      ],
      "name": "Giovanna Macanhã Scremin"
    },
    {
      "affs": [
        0
      ],
      "name": "Neel Patel"
    },
    {
      "affs": [
        3
      ],
      "name": "Amal Zakani"
    },
    {
      "affs": [
        4
      ],
      "name": "Mihaela Ioana Mariș"
    },
    {
      "affs": [
        1
      ],
      "name": "Tomasz Płonek"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6x75t7yhm19sm.bib",
  "cited_by": 0,
  "doi": "10.34172/jcvtr.33605",
  "fulltext_url": "https://europepmc.org/articles/PMC13677610",
  "id": "6x75t7yhm19sm",
  "issns": [
    "2008-5117",
    "2008-6830"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898308",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Cerebrovascular and Carotid Artery Diseases"
    ]
  ],
  "openalex": "W7219744879",
  "pdf_url": "https://europepmc.org/articles/PMC13677610?pdf=render",
  "pmcid": "PMC13677610",
  "pmid": "42898308",
  "published": "2026-06-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6x75t7yhm19sm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42898308",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898308"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Cerebrovascular and Carotid Artery Diseases",
      "subfield": "general"
    }
  ],
  "title": "Does Concurrent Carotid Endarterectomy with Coronary Artery Bypass Grafting Improve Outcomes in Patients with Dual Arterial Disease? A Systematic Review and Meta-Analysis.",
  "title_text": "Does Concurrent Carotid Endarterectomy with Coronary Artery Bypass Grafting Improve Outcomes in Patients with Dual Arterial Disease? A Systematic Review and Meta-Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:42Z",
  "url": "https://research.draconitic.com/paper/6x75t7yhm19sm",
  "venue": "Journal of cardiovascular and thoracic research",
  "versions": []
}