{
  "abstract": "In pancreatic ductal adenocarcinoma (PDAC), the fibroblastic stroma constitutes most of the tumor mass and is remarkably devoid of functional blood vessels. This raises an unresolved question of how PDAC cells obtain essential metabolites and water-insoluble lipids. We have found a critical role for cancer-associated fibroblasts (CAFs) in obtaining and transferring lipids from blood-borne particles to PDAC cells via trogocytosis of CAF plasma membranes. We have also determined that CAF-expressed phospholipid scramblase anoctamin 6 (ANO6) is an essential CAF trogocytosis regulator required to promote PDAC cell survival. During trogocytosis, cancer cells and CAFs form synapse-like plasma membranes contacts that induce cytosolic calcium influx in CAFs via Orai channels. This influx activates ANO6 and results in phosphatidylserine exposure on CAF plasma membrane initiating trogocytosis and transfer of membrane lipids, including cholesterol, to PDAC cells. Importantly, ANO6-dependent trogocytosis also supports the immunosuppressive function of pancreatic CAFs towards cytotoxic T cells by promoting transfer of excessive amounts of cholesterol. Further, blockade of ANO6 antagonizes tumor growth via disruption of delivery of exogenous cholesterol to cancer cells and reverses immune suppression suggesting a potential new strategy for PDAC therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Equipe de Recherche Labellisée \"Ligue Contre le Cancer\", INSERM UMR-1037, CNRS ERL5294, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse, Toulouse, France",
    "Program in Cancer Signaling & Microenvironment, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, USA",
    "The Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA",
    "Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse, INSERM UMR-107, CNRS ERL5294, Equipe de Recherche Labellisée \"Ligue Contre le Cancer\", Toulouse, France",
    "Program in Cancer Signaling & Microenvironment, Fox Chase Cancer Center, Philadelphia, PA 9, USA",
    "The Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA",
    "Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA",
    "Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 1910, USA",
    "Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA",
    "Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA",
    "Department of Bioengineering, Temple University, Philadelphia, PA, 19140, USA",
    "Bioengineering Department, College of Engineering, Temple University, Philadelphia, PA, USA",
    "Molecular and Cell Biology and Genetics (MCBG) Program, Drexel University College of Medicine, Philadelphia, PA 19102, USA",
    "Henry Ford Pancreatic Cancer Center, Detroit, MI, USA",
    "Molecular and Cell Biology and Genetics (MCBG) Program, Drexel University College of Medicine, Philadelphia, PA, USA",
    "Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Philadelphia, PA 19104, USA",
    "Hôpital Beaujon - INSERM U114 - Clichy, France",
    "Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA",
    "Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Philadelphia, PA, USA",
    "Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA",
    "Hôpital Beaujon, INSERM, Clichy, France",
    "Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Philadelphia, PA, USA",
    "Program in Cancer Signaling & Microenvironment, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, USA. Edna.Cukierman@fccc.edu",
    "The Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA. Edna.Cukierman@fccc.edu",
    "Program in Cancer Signaling & Microenvironment, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, USA. Igor.Astsaturov@fccc.edu",
    "The Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA. Igor.Astsaturov@fccc.edu"
  ],
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  "author_total": 43,
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      "name": "Edna Cukierman",
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      "name": "Igor A. Astsaturov",
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  "bibtex": "https://research.draconitic.com/paper/6xbvjz1mg3vy9.bib",
  "cited_by": 25,
  "doi": "10.1038/s43018-026-01265-5",
  "fulltext_url": null,
  "id": "6xbvjz1mg3vy9",
  "issns": [
    "2662-1347"
  ],
  "landing_url": "https://doi.org/10.1038/s43018-026-01265-5",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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  "native_subjects": [
    [
      "openalex",
      "1306|Cancer, Lipids, and Metabolism"
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  "pdf_url": "https://www.nature.com/articles/s43018-026-01265-5.pdf",
  "pmcid": "PMC10515956",
  "pmid": "37745612",
  "published": "2026-10-30",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/6xbvjz1mg3vy9.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T13:20:37Z",
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      "url": "https://doi.org/10.1038/s43018-026-01265-5"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer, Lipids, and Metabolism",
      "subfield": "oncology"
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  ],
  "title": "ANO6-mediated trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer cell growth and immune suppression",
  "title_text": "ANO6-mediated trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer cell growth and immune suppression",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:05Z",
  "url": "https://research.draconitic.com/paper/6xbvjz1mg3vy9",
  "venue": "Nature Cancer",
  "versions": []
}