{
  "abstract": "Introduction: Risk reducing salpingo-oophorectomy with delayed oophorectomy is an alternative preventive strategy to prevent tubo-ovarian carcinoma. Its oncological safety is currently under investigation within different clinical trials. Case: After a previous salpingectomy, a 37-year-old BRCA1 pathogenic variant carrier developed a carcinoma in the abdominal cavity, which had spread extensively throughout the abdomen. She had chosen the alternative risk-reducing salpingectomy with delayed oophorectomy as tubo-ovarian carcinoma prevention strategy The salpingectomy was performed at age 35, two years prior to the diagnosis of carcinoma. Radiologically, the tumor appeared to originate from the left ovary with lymphadenopathy, hydronephrosis, and peritoneal carcinomatosis. Incomplete debulking surgery was performed with en bloc resection of the uterus, ovaries, rectosigmoid,appendix, and distal part of the left ureter. After extensive analysis with pathology revision, the tumor was classified as a poorly differentiated sarcomatoid urothelial cell carcinoma. Molecular testing showed the tumor had a BRCA1 pathogenic variant. Conclusion: This case illustrates the importance of a structured clinical trial setting for the investigation of cancer prevention strategies as it ensures extensive follow-up and comprehensive pathological (re)assessment to warrant patient safety.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Radboud university Medical Center, Nijmegen, The Netherlands; Corresponding author at: Department of Gynecology and Obstetrics, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.",
    "Department of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway",
    "Department of Obstetrics and Gynecology, Radboud university Medical Center, Nijmegen, The Netherlands",
    "Department of Pathology, Radboud university Medical Center, Nijmegen, The Netherlands",
    "Department of Pathology, Oslo University Hospital, Oslo, Norway"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
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        0
      ],
      "name": "Tamar A. Gootzen"
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    {
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      "name": "Alda Birgsdottir"
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        2
      ],
      "name": "Miranda P. Steenbeek"
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      "name": "Michiel Simons"
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    {
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      "name": "Guro H. Gloersen"
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    {
      "affs": [
        1
      ],
      "name": "Anne Dørum"
    },
    {
      "affs": [
        2
      ],
      "name": "Joanne A. de Hullu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6xh8z12etky47.bib",
  "cited_by": 0,
  "doi": "10.1016/j.gore.2026.102232",
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  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
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      "1311|BRCA gene mutations in cancer"
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  "pdf_url": "https://europepmc.org/articles/PMC13718501?pdf=render",
  "pmcid": null,
  "pmid": "42959853",
  "published": "2026-10-14",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/6xh8z12etky47.ris",
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    {
      "first_seen": "2026-10-30T13:44:35Z",
      "native_id": "af05085cf1ed442486a1ca2c8b98748c",
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      "url": "https://doi.org/10.1016/j.gore.2026.102232"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|BRCA gene mutations in cancer",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "A urothelial cell carcinoma in the abdominal cavity after salpingectomy for tubo-ovarian carcinoma risk reduction in a",
  "title_text": "A urothelial cell carcinoma in the abdominal cavity after salpingectomy for tubo-ovarian carcinoma risk reduction in a",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:31Z",
  "url": "https://research.draconitic.com/paper/6xh8z12etky47",
  "venue": "Gynecologic Oncology Reports",
  "versions": []
}