{
  "abstract": "Elevated FGF23 is associated with bone microarchitectural deterioration in chronic kidney dis-ease-mineral and bone disorder (CKD-MBD). While roxadustat (a HIF-PHI) is established for the treatment of renal anemia, its potential bone-protective effects in CKD-MBD remain unclear. We investigated whether roxadustat ameliorates femoral microarchitectural deterioration in CKD-MBD rats in association with FGF23 downregulation and restoration of Wnt/β-catenin signaling. A CKD-MBD rat model was established by unilateral nephrectomy and adenine gavage, and animals were randomized into sham, model, and roxadustat (50 or 100 mg/kg, three times weekly) groups for 8 weeks. Renal function, hematological indices, calcium-phosphate parame-ters, and femoral microarchitecture were evaluated, and target protein levels (FGF23, FGFR1, DKK1, β-catenin) were assessed by Western blotting and immunohistochemistry. Roxadustat improved renal function, ameliorated the reduction in erythroid parameters, and restored calcium-phosphate homeostasis. Systemically, it mitigated micro-inflammation by reducing serum CRP and hepcidin, and downregulated serum FGF23 levels as well as tissue FGF23 expression in kidney and bone. In conclusion, the bone-protective effect of roxadustat occurs synchronously with systemic micro-inflammation mitigation, FGF23 downregulation, and Wnt/β-catenin signaling restoration. These findings highlight its pleiotropic therapeutic potential in CKD-MBD management, suggesting a synergistic benefit associated with both systemic metabolic recovery and local skeletal regulation.",
  "abstract_shown": true,
  "affiliations": [
    "Research Center for High Altitude Medicine, Key Laboratory of High Altitude Medicine (Ministry of Education), Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai-Utah Joint Research Key Lab for High Altitude Medicine), Qinghai University",
    "Clinical Research Center for Chronic Kidney Disease in Qinghai Province",
    "Qinghai University",
    "Department of Public Health, Medical College, Qinghai University",
    "Department of Nephrology, The Affiliated Hospital of Qinghai University",
    "Department of Nephrology, Beijing Hospital",
    "Department of Geriatrics, The Affiliated Hospital of Qinghai University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zhenzhen Shan"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Yan Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Xue Sun"
    },
    {
      "affs": [
        5
      ],
      "name": "Zhan Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Jinlan Ma"
    },
    {
      "affs": [
        6
      ],
      "name": "Yanjun Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Shaozheng Ai"
    },
    {
      "affs": [
        4
      ],
      "name": "Yanyan Yang"
    },
    {
      "affs": [
        0,
        1,
        4
      ],
      "name": "Pengli Luo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6xvs7ywzmb79q.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1957451",
  "fulltext_url": null,
  "id": "6xvs7ywzmb79q",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1957451/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6xvs7ywzmb79q.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:33Z",
      "native_id": "10.3389/fphar.2026.1957451",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1957451/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1663-9812",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Roxadustat ameliorates bone microarchitectural deterioration in CKD-MBD rats in association with mitigated systemic micro-inflammation and restored FGF23–Wnt/β-catenin signaling",
  "title_text": "Roxadustat ameliorates bone microarchitectural deterioration in CKD-MBD rats in association with mitigated systemic micro-inflammation and restored FGF23–Wnt/β-catenin signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:21:10Z",
  "url": "https://research.draconitic.com/paper/6xvs7ywzmb79q",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}