{
  "abstract": "Palladium-catalyzed coupling reactions, such as the well-established Suzuki and Hiyama couplings of benzylic ammonium salts, have been widely employed for the synthesis of diphenylmethanes. In contrast, the decarboxylative coupling strategy for constructing such scaffolds remains largely unexplored. This paper reports a Pd-Cu-Ag trimetallic synergistic catalytic system that enables efficient access to diphenylmethane derivatives through C(sp3)–N bond cleavage of amines and decarboxylation of carboxylic acids. This innovative methodology involves the in situ generation of carbene precursors via Pd-catalyzed, electron-deficient alkyne-mediated deamination of tertiary amines, along with the formation of activated nucleophilic species through Cu/Ag-catalyzed decarboxylation of carboxylic acids. The protocol features mild reaction conditions, high efficiency, and excellent functional group tolerance.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, Belgium, B-3001",
    "College of Chemistry and Chemical Engineering",
    "Shanghai University of Engineering Science",
    "Peoples’ Friendship University of Russia (RUDN University, Miklukho-Maklaya Street 6, Moscow, Russia, 117198"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yujuan Xie",
      "orcid": "0009-0008-9746-2610"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Liliang Huang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Huangdi Feng"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Erik V. Van der Eycken"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6y77gafvtyzj3.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010185/v1",
  "fulltext_url": null,
  "id": "6y77gafvtyzj3",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010185/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Catalytic Cross-Coupling Reactions"
    ]
  ],
  "openalex": "W7221065318",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010185/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/6y77gafvtyzj3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15010185",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010185/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic Cross-Coupling Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Pd-Cu-Ag Trimetallic Synergistic Catalysis for Decarboxylative/Deaminative Coupling of Carboxylic acids with Tertiary Amines",
  "title_text": "Pd-Cu-Ag Trimetallic Synergistic Catalysis for Decarboxylative/Deaminative Coupling of Carboxylic acids with Tertiary Amines",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/6y77gafvtyzj3",
  "venue": "ChemRxiv",
  "versions": []
}