{
  "abstract": "Purpose\n\nThis study evaluated electroacupuncture (EA) as adjunctive therapy after peripheral nerve repair in a rat model.Methods\n\nMale Wistar rats underwent right sciatic nerve transection followed by neurorrhaphy and were randomized into EA or control groups. EA was performed twice weekly for 12 weeks. Sensory and motor recovery were assessed by nociceptive, mechanical, thermal, and sciatic functional index tests. Histological analyses evaluated Schwann cell and vascular densities, and gastrocnemius muscle weight was measured at euthanasia.Results\n\nSensory recovery was significantly greater in the EA group, with higher pain (3 [3-3.75] versus 2 [1-2], p = 0.02), pressure (2.5 [1.25-3] versus 0 [0-1], p = 0.009), and thermal sensitivity scores (2 [2-2.75] versus 0 [0-0], p = 0.02). Motor recovery and vascular density did not differ between groups. Distal Schwann cell density was significantly higher in the EA group (73.5 [67.4-74.1] versus 34.7 [34.5-38.4], p = 0.014). Gastrocnemius muscle weight was reduced in operated limbs in both groups, without intergroup differences.Conclusion\n\nEA improved sensory recovery and increased distal Schwann cell density, supporting its potential as an adjunctive therapy after peripheral nerve repair.",
  "abstract_shown": true,
  "affiliations": [
    "Universidade de São Paulo - School of Medicine - Department of Surgery - São Paulo (SP) - Brazil.",
    "Universidade de São Paulo - School of Medicine - Laboratory of Plastic Surgery and Regenerative Medicine - São Paulo (SP) - Brazil.",
    "Universidade de São Paulo - Center of Acupuncture - Department of Orthopedics and Traumatology - São Paulo (SP) - Brazil.",
    "Sociedade Brasileira de Microcirurgia Reconstrutiva - Rio de Janeiro (RJ) - Brazil.",
    "Asociación Latinoamericana de Microcirurgía - Rio de Janeiro (RJ) - Brazil.",
    "Universidade Estadual Paulista - School of Medicine - Department of Plastic Surgery - Botucatu (SP) - Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Felipe Giraldo Alvarez Gonçalves",
      "orcid": "0009-0001-3931-9196"
    },
    {
      "affs": [
        2
      ],
      "name": "Liaw Wen Chao",
      "orcid": "0000-0003-0536-2273"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Emily Caroline da Fonseca Sampaio",
      "orcid": "0009-0004-8459-1385"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Adriano Augusto Domingos Neto",
      "orcid": "0000-0003-2791-1165"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Luiza Rafih Abud",
      "orcid": "0009-0003-3873-1335"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "André Salo Buslik Hazan",
      "orcid": "0009-0003-7490-2728"
    },
    {
      "affs": [
        5
      ],
      "name": "Fausto Viterbo",
      "orcid": "0000-0001-7282-7566"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rolf Gemperli",
      "orcid": "0000-0001-9913-6079"
    },
    {
      "affs": [
        1
      ],
      "name": "Cristina Pires Camargo",
      "orcid": "0000-0002-3134-0003"
    },
    {
      "affs": [
        2
      ],
      "name": "Wu Tu Hsing",
      "orcid": "0000-0002-7019-7342"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6yefnskscfdty.bib",
  "cited_by": 0,
  "doi": "10.1590/acb415726",
  "fulltext_url": "https://europepmc.org/articles/PMC13686333",
  "id": "6yefnskscfdty",
  "issns": [
    "0102-8650",
    "1678-2674"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912005",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Nerve injury and regeneration"
    ]
  ],
  "openalex": "W7222966328",
  "pdf_url": "https://europepmc.org/articles/PMC13686333?pdf=render",
  "pmcid": "PMC13686333",
  "pmid": "42912005",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6yefnskscfdty.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42912005",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912005"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Nerve injury and regeneration",
      "subfield": "neuroscience"
    }
  ],
  "title": "Electroacupuncture following microsurgical neurorrhaphy: functional and histological outcomes in a rat model.",
  "title_text": "Electroacupuncture following microsurgical neurorrhaphy: functional and histological outcomes in a rat model.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/6yefnskscfdty",
  "venue": "Acta cirurgica brasileira",
  "versions": []
}