{
  "abstract": "Background Patients receiving clopidogrel who undergo urgent CABG before the recommended 5-day washout period are at increased risk of perioperative bleeding. This study evaluated whether intraoperative hemoadsorption can reduce bleeding in such patients. Methods Patients undergoing CABG within 24 h of clopidogrel discontinuation were randomized 1:1 to intraoperative hemoadsorption (Group 1) or control (Group 2). In the intervention group, the device was incorporated into the cardiopulmonary bypass (CPB) circuit. Efficacy was assessed by 24-hour chest tube drainage (CTD), blood product transfusions and surgical revisions for bleeding control. Results A total of 50 patients were randomized (mean age 64 ± 8.6 years, 82% male). There were no differences in baseline characteristics between groups. Group 1 showed significantly reduced median 24-hr CTD of 300mL [250–400] vs. 500mL [400–700], p = 0.0003, transfusions of packed red blood cells 0 [0–1] vs. 1 [0–2] units, p = 0.047), fresh frozen plasma 0 [0–0] vs. 2 [2–3] units, p < 0.0001) and platelets 0 [0–0] vs. 2 [1–3] units, p < 0.0001 compared with Group 2. One revision for bleeding control occurred in Group 2 (4.0%). No device-related serious adverse events were observed. Conclusion In this cohort of clopidogrel-treated patients undergoing CABG within 24 h of discontinuation, intraoperative hemoadsorption was associated with lower postoperative bleeding and transfusion requirements.",
  "abstract_shown": true,
  "affiliations": [
    "National Heart Center, Royal Hospital",
    "Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences",
    "Cardiac anesthesia consultant, National Heart Centre, Royal hospital",
    "CytoSorbents Europe GmbH",
    "CytoSorbents Inc",
    "Department of Cardiac Surgery, Shariati Hospital, Tehran University of Medical Sciences"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alireza Jahangirifard"
    },
    {
      "affs": [
        1
      ],
      "name": "Seyed Bashir Mirtajani"
    },
    {
      "affs": [
        2
      ],
      "name": "Is´haq Al-Aamri"
    },
    {
      "affs": [
        2
      ],
      "name": "Kumait Al-Lawati"
    },
    {
      "affs": [
        1
      ],
      "name": "Mandana Hosseinzadeh"
    },
    {
      "affs": [
        3
      ],
      "name": "Daniel Wendt"
    },
    {
      "affs": [
        4
      ],
      "name": "Efthymios N. Deliargyris"
    },
    {
      "affs": [
        5
      ],
      "name": "Mohammad Hossein Mandegar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6yft1bfe411vc.bib",
  "cited_by": 0,
  "doi": "10.1186/s13019-026-04607-7",
  "fulltext_url": "https://doi.org/10.1186/s13019-026-04607-7",
  "id": "6yft1bfe411vc",
  "issns": [
    "1749-8090"
  ],
  "landing_url": "https://doi.org/10.1186/s13019-026-04607-7",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RD1-811"
    ],
    [
      "lcc",
      "RD78.3-87.3"
    ],
    [
      "openalex",
      "2705|Antiplatelet Therapy and Cardiovascular Diseases"
    ]
  ],
  "openalex": "W7171358573",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/6yft1bfe411vc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:19Z",
      "native_id": "2e4cdcc3230e4b05be798772ff3c4e1a",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s13019-026-04607-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Antiplatelet Therapy and Cardiovascular Diseases",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Randomized pilot trial of intraoperative hemoadsorption in clopidogrel treated patients undergoing urgent coronary artery bypass grafting",
  "title_text": "Randomized pilot trial of intraoperative hemoadsorption in clopidogrel treated patients undergoing urgent coronary artery bypass grafting",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:19Z",
  "url": "https://research.draconitic.com/paper/6yft1bfe411vc",
  "venue": "Journal of Cardiothoracic Surgery",
  "versions": []
}