{
  "abstract": "Originally thought to be a major endocytic portal, caveolae function as a membrane buffer, whereby caveolae flattening protects the plasma membrane from rupture under mechanical stress, such as hypotonic shock. However, the fate of the caveolae coat protein caveolin-1 upon caveolae flattening is not known. Here, extended hypotonic shock induces ubiquitin-independent, CLIC-dependent endocytosis of caveolin-1 to large, intracellular, CD44-positive, pH-neutral lysosomal vacuoles negative for multivesicular body markers. Caveolin-1 recycles from these vacuoles to the plasma membrane upon return to isotonic conditions. Caveolin-1 internalization occurs upon reduced cell volume due to extended hypotonic shock as well as in low-tension cells grown on reduced-stiffness hydrogels. Upon hypertonic shock, caveolin-1 internalization occurs in PC3 cells, lacking cavin-1 and caveolae, and is inhibited upon cavin-1 reintroduction. CLIC endocytosis of non-caveolar caveolin-1 to neutral pH lysosomal vacuoles identifies a non-caveolar endocytic and recycling pathway for caveolin-1 in response to reduced membrane tension.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Timothy Wong"
    },
    {
      "name": "Matheus Lima"
    },
    {
      "name": "Aditya Nagrath"
    },
    {
      "name": "Y. Lydia Li"
    },
    {
      "name": "Bharat Joshi"
    },
    {
      "name": "Fuiboon Kai"
    },
    {
      "name": "Ivan Robert Nabi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6yk2ah5gsk08y.bib",
  "cited_by": 0,
  "doi": "10.1016/j.celrep.2026.117373",
  "fulltext_url": null,
  "id": "6yk2ah5gsk08y",
  "issns": [
    "2211-1247",
    "2211-1247"
  ],
  "landing_url": "https://hal.science/hal-05785144v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1307|Caveolin-1 and cellular processes"
    ]
  ],
  "openalex": "W4413353042",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": "Elsevier Inc",
  "ris": "https://research.draconitic.com/paper/6yk2ah5gsk08y.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "hal-05785144",
      "source": "hal",
      "url": "https://hal.science/hal-05785144v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Caveolin-1 and cellular processes",
      "subfield": "cell-biology"
    }
  ],
  "title": "CLIC-dependent internalization of caveolin-1 to lysosomal vacuoles in response to osmotic regulation",
  "title_text": "CLIC-dependent internalization of caveolin-1 to lysosomal vacuoles in response to osmotic regulation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:50Z",
  "url": "https://research.draconitic.com/paper/6yk2ah5gsk08y",
  "venue": "Cell Reports",
  "versions": []
}