{
  "abstract": "To systematically map the 35-year intellectual evolution of stem cell research in sepsis and identify emerging frontiers for clinical translation. We retrieved 3890 publications (1990-2025) from the Web of Science Core Collection. Multi-dimensional bibliometric analyses, including co-citation networks, keyword bursts, and alluvial flow mapping, were performed using CiteSpace, HistCite, and R to delineate the field's trajectory. Annual publications increased significantly, peaking in 2024, with the USA and China as primary contributors. The research focus has undergone a major paradigm shift: from early \"bone marrow transplantation\" and hematopoietic reconstitution (1990s-2000s) to the immunomodulatory mechanisms of \"mesenchymal stem cells\" (2010s). Currently, the field has entered a \"cell-free\" era, characterized by intense research into \"extracellular vesicles\" and \"exosomes\" (2021-2025). Alluvial analysis identified \"cancer\", \"immunotherapy\", and \"COVID-19\" as dominant integrated modules. Notably, the emergence of \"guidelines\" and \"precision care\" highlights a growing emphasis on clinical standardization and targeted treatment for sepsis-induced organ failure. This study demonstrates that the frontier of sepsis therapy is moving toward refined, secretome-based biologics. Our findings provide a strategic roadmap for researchers to prioritize high-potential therapeutic targets and for clinicians to design more focused trials, ultimately accelerating the integration of stem cell-derived products into mainstream sepsis management.",
  "abstract_shown": true,
  "affiliations": [
    "The Fifth People's Hospital of Qinghai Province, Qinghai Province Cancer Hospital, Xining, Qinghai, People's Republic of China.",
    "Wuzhong People's Hospital, Wuzhong, Ningxia Hui Autonomous Region, People's Republic of China.",
    "The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kaiming Han"
    },
    {
      "affs": [
        1
      ],
      "name": "Hui Ding"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiying Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Junbin Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Yizheng Zu",
      "orcid": "0000-0003-3030-987X"
    },
    {
      "affs": [
        0
      ],
      "name": "Rongsheng Han"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6ykav5kcm831w.bib",
  "cited_by": 0,
  "doi": "10.2147/jir.s578516",
  "fulltext_url": "https://europepmc.org/articles/PMC13744261",
  "id": "6ykav5kcm831w",
  "issns": [
    "1178-7031"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999863",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2706|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7225073486",
  "pdf_url": "https://europepmc.org/articles/PMC13744261?pdf=render",
  "pmcid": "PMC13744261",
  "pmid": "42999863",
  "published": "2026-11-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6ykav5kcm831w.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42999863",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999863"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2706|Sepsis Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Trends and Frontiers in Stem Cell Research for Sepsis: A Bibliometric Analysis (1990-2025).",
  "title_text": "Trends and Frontiers in Stem Cell Research for Sepsis: A Bibliometric Analysis (1990-2025).",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/6ykav5kcm831w",
  "venue": "Journal of inflammation research",
  "versions": []
}