{
  "abstract": "Arterial stiffness is a significant precursor of cardiovascular diseases (CVD), influenced by calcium metabolic homeostasis. The urinary calcium-to-creatinine ratio (UCa/Cr) reflects calcium excretion status and may be associated with arterial stiffness. This study included 21,834 subjects from annual health check-ups (2017–2020) and a prospective cohort of 3219 subjects followed from 2020 to 2024 at the Third Xiangya Hospital in Hunan, China. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV) and classified as normal-to-mild (baPWV ≤ 1700 cm/s) or moderate-to-severe arterial stiffness (moderate-to-severe AS). Logistic regression models were used for cross-sectional analysis, and Cox proportional hazards models were used for the cohort analysis. In the cross-sectional study, a significant nonlinear association was observed between UCa/Cr and moderate-to-severe AS ( P overall < 0.001, P nonlinearity = 0.010). Compared with the lowest UCa/Cr group (< 0.049), the highest group (≥ 0.109) had a 36% higher odds of moderate‑to‑severe AS (aOR = 1.36, 95% CI: 1.11, 1.65). In the cohort study, over 7144 person-years of follow-up, 145 individuals developed moderate-to-severe AS. A significant overall association was observed between UCa/Cr and the risk of moderate-to-severe AS ( P overall = 0.014). Compared with the lowest UCa/Cr group (< 0.049), the highest group (≥ 0.109) had more than a two-fold higher risk of incident moderate‑to‑severe AS (aHR = 2.12, 95% CI: 1.18, 3.82). Further adjustment for continuous SBP and DBP attenuated both associations, which were no longer statistically significant. In the primary analyses, UCa/Cr was associated with both prevalent and incident moderate-to-severe AS, with the association most evident at higher UCa/Cr levels, but the findings were sensitive to adjustment for SBP.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Ying Li"
    },
    {
      "name": "Wenbin Ouyang"
    },
    {
      "name": "Hao Wu"
    },
    {
      "name": "Zhiqing Zhao"
    },
    {
      "name": "Pingting Yang"
    },
    {
      "name": "Yuexiang Qin"
    },
    {
      "name": "Jing Deng"
    },
    {
      "name": "Xin Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6z2a2w5b3myt8.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-76582-x",
  "fulltext_url": null,
  "id": "6z2a2w5b3myt8",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-76582-x",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Cardiovascular Health and Disease Prevention"
    ]
  ],
  "openalex": "W7223133444",
  "pdf_url": "https://www.nature.com/articles/s41598-026-76582-x_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/6z2a2w5b3myt8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:33Z",
      "native_id": "10.1038/s41598-026-76582-x",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-76582-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Health and Disease Prevention",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Association between urine calcium creatinine ratio and arterial stiffness among Chinese adults undergoing health screening with normal renal function",
  "title_text": "Association between urine calcium creatinine ratio and arterial stiffness among Chinese adults undergoing health screening with normal renal function",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:33Z",
  "url": "https://research.draconitic.com/paper/6z2a2w5b3myt8",
  "venue": "Scientific Reports",
  "versions": []
}