{
  "abstract": "Cordyceps polysaccharides (CSP) have shown protective potential in ischemic stroke, but their central inflammatory mechanisms remain unclear. This study examined whether the effects of CSP are associated with interleukin-17 (IL-17)/nuclear factor kappa B (NF-κB)-related signaling. Publicly available human transcriptomic datasets were integrated and analyzed to identify inflammation-related pathways in ischemic stroke, and a public mouse middle cerebral artery occlusion (MCAO) single-cell RNA sequencing (RNA-seq) dataset was analyzed to identify relevant brain cell populations. IL-17 receptor A (IL-17RA) knockdown was performed in oxygen–glucose deprivation (OGD)-exposed SH-SY5Y cells. The effects of CSP were further evaluated in MCAO rats and OGD-exposed BV-2 cells. Bioinformatics analyses showed enrichment of IL-17 and NF-κB signaling in ischemic stroke datasets, and single-cell module-score analysis showed that microglia exhibited the largest MCAO-associated increase in IL-17/NF-κB-related module scores. IL-17RA knockdown improved the viability of OGD-exposed SH-SY5Y cells. In MCAO rats, CSP improved neurological and behavioral outcomes, increased cerebral blood flow, and reduced cerebral edema, infarct volume, neuronal loss, microglial responses, and IL-17A/IL-17RA expression. In OGD-exposed BV-2 cells, CSP reduced IL-17A, IL-17RA, NF-κB activator 1 (ACT1), tumor necrosis factor receptor-associated factor 6 (TRAF6), IL-1β, IL-6, and the phosphorylated p65/total p65 ratio. These findings suggest that the protective effects of CSP in ischemic stroke models are associated with attenuation of IL-17/NF-κB-related neuroinflammation.",
  "abstract_shown": true,
  "affiliations": [
    "School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China",
    "School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Huizhang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yifan Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan Liao",
      "orcid": "0000-0002-5684-0338"
    },
    {
      "affs": [
        1
      ],
      "name": "Saiwen Xi"
    },
    {
      "affs": [
        0
      ],
      "name": "Xia Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Huiming Qi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yihui Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Yutong Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Mujie Fang"
    },
    {
      "affs": [
        0
      ],
      "name": "Changhua Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Cong Gai",
      "orcid": "0009-0002-4394-299X"
    },
    {
      "affs": [
        0
      ],
      "name": "Yibo Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6z46z8877trrb.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209035",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705458/?tool=EBI",
  "id": "6z46z8877trrb",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9035",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2808|Neuroinflammation and Neurodegeneration Mechanisms"
    ]
  ],
  "openalex": "W7221562817",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705458/pdf/?tool=EBI",
  "pmcid": "PMC13705458",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/6z46z8877trrb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27209035",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9035"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13705458",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705458"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neuroinflammation and Neurodegeneration Mechanisms",
      "subfield": "neurology"
    }
  ],
  "title": "Cordyceps Polysaccharides Attenuate Experimental Ischemic Stroke Injury: Association with IL-17/NF-κB Signaling",
  "title_text": "Cordyceps Polysaccharides Attenuate Experimental Ischemic Stroke Injury: Association with IL-17/NF-κB Signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:40Z",
  "url": "https://research.draconitic.com/paper/6z46z8877trrb",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}