{
  "abstract": "Heart failure with preserved ejection fraction (HFpEF) lacks effective therapies in part due to an incomplete understanding of cardiomyocyte-specific mitochondrial mechanisms involved in cardiac dysfunction. Using an aged, multihit mouse model that recapitulates key features of human HFpEF in both sexes, we demonstrate that impaired cardiac reserve is associated with reduced mitochondrial respiratory capacity and coordinated suppression of mitochondrial protein quality-control pathways. These findings identify mitochondrial proteostasis failure as a central mechanism limiting energetic reserve in HFpEF cardiomyocytes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xuan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yiling Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jussara M. do Carmo"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandre A. da Silva"
    },
    {
      "affs": [
        0
      ],
      "name": "Alan J. Mouton"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana C.M. Omoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Lucas Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "John E. Hall"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhen Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6zvbpqvbpe96a.bib",
  "cited_by": 0,
  "doi": "10.1152/ajpheart.00304.2026",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722021/",
  "id": "6zvbpqvbpe96a",
  "issns": [
    "0363-6135",
    "1522-1539"
  ],
  "landing_url": "https://doi.org/10.1152/ajpheart.00304.2026",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Mitochondrial Function and Pathology"
    ]
  ],
  "openalex": "W7214378197",
  "pdf_url": null,
  "pmcid": "PMC13722021",
  "pmid": "42789924",
  "published": "2026-09-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6zvbpqvbpe96a.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:22:36Z",
      "native_id": "PMC13722021",
      "source": "pmc",
      "url": "https://doi.org/10.1152/ajpheart.00304.2026"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Mitochondrial Function and Pathology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction",
  "title_text": "Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:36Z",
  "url": "https://research.draconitic.com/paper/6zvbpqvbpe96a",
  "venue": "American journal of physiology. Heart and circulatory physiology",
  "versions": []
}