{
  "abstract": "Epithelial dynamics are often studied using two-dimensional models that omit cell height. Here, we investigate how this third dimension influences tissue fluidization driven by cell self-propulsion. We identify three effects absent from conventional 2D models. First, cell height controls fluidization through a reentrant transition: squamous and columnar tissues are more resistant to fluidization than cuboidal ones. Second, neighbor exchanges through transient scutoid states substantially enhance cell motility, compared to classic T1 transitions. Third, self-propelling cells develop pronounced apicobasal shape asymmetry, with the experimentally less accessible basal surface providing a more accurate indicator of cells' target shape index and motility.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2610.20030",
  "author_total": 3,
  "authors": [
    {
      "name": "Toshikaze Chiba"
    },
    {
      "name": "Jan Rozman"
    },
    {
      "name": "Matej Krajnc"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/708hbfxghzft4.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2610.20030",
  "fulltext_url": null,
  "id": "708hbfxghzft4",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2610.20030",
  "language": null,
  "licence": "CC0-1.0",
  "licence_label": "CC0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/publicdomain/zero/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "physics.bio-ph"
    ],
    [
      "openalex",
      "1307|Cellular Mechanics and Interactions"
    ]
  ],
  "openalex": "W7222207834",
  "pdf_url": "https://arxiv.org/pdf/2610.20030",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/708hbfxghzft4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:29:31Z",
      "native_id": "2610.20030",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2610.20030"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:physics.bio-ph",
      "subfield": "biological-medical"
    }
  ],
  "title": "Full Three-dimensional Cell Geometry Matters for Epithelial Fluidization",
  "title_text": "Full Three-dimensional Cell Geometry Matters for Epithelial Fluidization",
  "type": "preprint",
  "updated_at": "2026-10-30T12:29:31Z",
  "url": "https://research.draconitic.com/paper/708hbfxghzft4",
  "venue": "arXiv",
  "versions": []
}