{
  "abstract": "Background\n\nEarly risk stratification in septic shock requires transparent models based on variables available soon after clinical diagnosis of septic shock. We reanalysed a retrospective cohort using the original screening strategy: candidate predictors with univariable P < 0.05 were entered into multivariable logistic regression, and variables with multivariable P < 0.05 were retained in the final model.Methods\n\nThe analysis included 250 patients with complete 28-day outcome and laboratory data. The outcome was 28-day mortality. Candidate predictors comprised demographics, comorbidities, complete blood count, chemistry, coagulation, inflammatory markers, arterial pH, and PaO2/FiO2. Laboratory values were treated as the first available values within 24 h after clinical diagnosis of septic shock. The final fixed model and the complete model-development pipeline were internally validated using 1,000 bootstrap resamples. Discrimination, calibration, Brier score, ROC-derived cutoff, decision curve analysis, LAR comparison, restricted cubic spline analysis, VIF, and LASSO sensitivity analysis were reported.Results\n\nAmong 250 patients, 73 died by day 28 (29.2%). Univariable screening identified 12 candidate predictors, and multivariable screening retained lactate, D-dimer, and PaO2/FiO2. The final equation was logit(P) = 0.412145 + 0.250015 × Lactate + 0.046852 × D-dimer - 0.016820 × PaO2/FiO2. The apparent AUC was 0.902 (95% CI 0.864-0.940), and the optimism-corrected AUC for the fixed final model was 0.897. When the complete model-development pipeline was repeated within 1,000 bootstrap resamples, the optimism-corrected AUC was 0.875. The final model had higher discrimination than LAR alone [0.902 (0.864-0.940) vs. 0.719 (0.645-0.793); DeLong P < 0.001].Conclusions\n\nA selected logistic model using lactate, D-dimer, and PaO2/FiO2 provided internally validated early risk estimates for 28-day mortality. External validation is required before routine clinical use.",
  "abstract_shown": true,
  "affiliations": [
    "The Blood Transfusion Department, the First People's Hospital of Yibin City, Yibin, China.",
    "The Laboratory Department, the Third People's Hospital of Yibin City, Yibin, China.",
    "The Intensive Care Unit, the First People's Hospital of Yibin City, Yibin, China.",
    "The Laboratory Department, the First People's Hospital of Yibin City, Yibin, China.",
    "School of Laboratory Medicine, North Sichuan Medical College, Nanchong, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Liying Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Pu Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Jie Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Weilei Xiao"
    },
    {
      "affs": [
        4
      ],
      "name": "Wentao Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/70ct5pzgj30sx.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1864043",
  "fulltext_url": "https://europepmc.org/articles/PMC13710332",
  "id": "70ct5pzgj30sx",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948084",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7221712510",
  "pdf_url": "https://europepmc.org/articles/PMC13710332?pdf=render",
  "pmcid": "PMC13710332",
  "pmid": "42948084",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/70ct5pzgj30sx.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:34Z",
      "native_id": "MED:42948084",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948084"
    },
    {
      "first_seen": "2026-10-31T12:21:19Z",
      "native_id": "PMC13710332",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1864043"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "A laboratory-based selected logistic model for early prediction of 28-day mortality in patients with septic shock.",
  "title_text": "A laboratory-based selected logistic model for early prediction of 28-day mortality in patients with septic shock.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:19Z",
  "url": "https://research.draconitic.com/paper/70ct5pzgj30sx",
  "venue": "Frontiers in medicine",
  "versions": []
}