{
  "abstract": "Background/objectives\n\nOptimizing nitrogen fertilizer efficiency is crucial for sustainable agriculture, but the genetic basis of low-nitrogen (LN) tolerance in oat (Avena sativa L.), an important forage and grain crop, remains poorly characterized.Methods\n\nThis study investigated eleven LN tolerance phenotypes across 103 oat accessions using high-density resequencing markers, mixed-model association mapping (MLM), a FarmCPU sensitivity analysis, and Bayesian genetic architecture inference (BSLMM).Results\n\nNo locus achieved genome-wide Bonferroni significance, and Bayesian estimates indicated a low-to-moderate model-based PVE (0.10-0.23) with no clearly identified major-effect locus, suggesting that genomic selection represents a plausible future direction for LN tolerance in oat. At a suggestive threshold (p < 1 × 10⁻⁵), a cross-model intersection nominated a hypothesis-generating locus at 1D:349,799,042 associated with root dry weight. This locus showed haplotype-level phenotypic segregation (Wilcoxon p = 1.36 × 10⁻⁵) on the discovery panel and concordant signals between the two models (r = 0.92). The nearest nitrogen-metabolism-related gene, P5CDH (22.7 kb away), encodes Δ¹-pyrroline-5-carboxylate dehydrogenase, which catalyses the terminal step of proline catabolism, and its wheat ortholog was significantly down-regulated under nitrogen deficiency.Conclusions\n\nThese findings provide a testable hypothesis linking proline catabolism to oat root plasticity under low nitrogen and a framework for validation in larger panels.",
  "abstract_shown": true,
  "affiliations": [
    "College of Grassland Science, Inner Mongolia Agricultural University, Hohhot 010011, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yu Ling"
    },
    {
      "affs": [
        0
      ],
      "name": "Ziyang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuhao Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zihao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Haizhou Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lihui Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/70g2t9rjne2jz.bib",
  "cited_by": 0,
  "doi": "10.3390/genes17101314",
  "fulltext_url": "https://europepmc.org/articles/PMC13704421",
  "id": "70g2t9rjne2jz",
  "issns": [
    "2073-4425"
  ],
  "landing_url": "https://europepmc.org/article/MED/42938430",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Genetic Mapping and Diversity in Plants and Animals"
    ]
  ],
  "openalex": "W7223146001",
  "pdf_url": "https://europepmc.org/articles/PMC13704421?pdf=render",
  "pmcid": "PMC13704421",
  "pmid": "42938430",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/70g2t9rjne2jz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42938430",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42938430"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetic Mapping and Diversity in Plants and Animals",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Genome-Wide Association Mapping of Low-Nitrogen Tolerance in Hexaploid Oat Identifies a Suggestive Candidate Locus near P5CDH Associated with Root Dry Weight.",
  "title_text": "Genome-Wide Association Mapping of Low-Nitrogen Tolerance in Hexaploid Oat Identifies a Suggestive Candidate Locus near P5CDH Associated with Root Dry Weight.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/70g2t9rjne2jz",
  "venue": "Genes",
  "versions": []
}