{
  "abstract": "目的研究血清神经丝轻链蛋白（NfL）、胰岛素样生长因子-1（IGF-1）、神经轴突导向因子-1（Netrin-1）在青少年抑郁患者认知功能诊断中的临床价值。方法选取至郑州大学第一附属医院就诊的青少年抑郁患者103例为抑郁组，根据蒙特利尔认知评估量表（MoCA）评分分为非认知障碍组（54例）和认知障碍组（49例）。另选取同期至本院健康体检的青少年52例为健康组。收集记录抑郁组患者的临床资料和MoCA各类目评分；利用ELISA试剂盒检测血清NfL、IGF-1、Netrin-1。采用logistic回归分析青少年抑郁患者认知障碍的影响因素；采用spearman分析血清NfL、IGF-1、Netrin-1与MoCA评分的相关性；采用ROC分析血清NfL、IGF-1、Netrin-1对青少年抑郁患者认知障碍的诊断价值。结果抑郁组血清NfL水平高于健康组，IGF-1、Netrin-1水平低于健康组（P<0.05）。认知障碍组患者MoCA各类目评分均低于非认知障碍组（P<0.05）。认知障碍组超重或肥胖所占比例、重度抑郁所占比例、NfL水平高于非认知障碍组，IGF-1、Netrin-1水平低于非认知障碍组（P<0.05）。NfL［OR=2.993（95%CI：1.682，5.326）］为青少年抑郁患者认知障碍的危险因素，IGF-1［OR=0.351（95%CI：0.212，0.582）］、Netrin-1［OR=0.327（95%CI：0.176，0.609）］为青少年抑郁患者认知障碍的保护因素（P<0.05）。血清NfL与MoCA各类目评分均呈负相关，IGF-1、Netrin-1与MoCA各类目评分均呈正相关（P<0.05）。血清NfL、IGF-1、Netrin-1联合诊断青少年抑郁患者认知障碍的AUC为0.902，高于NfL、IGF-1、Netrin-1单独诊断（Z联合-NfL=2.757、Z联合-IGF-1=2.398、Z联合-Netrin-1=2.334，P<0.05）。结论青少年抑郁合并认知障碍患者血清NfL水平较高，IGF-1、Netrin-1水平较低，NfL、IGF-1、Netrin-1水平与青少年抑郁患者的认知功能相关，联合血清NfL、IGF-1、Netrin-1可诊断青少年抑郁认知障碍患者。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "何丹丹"
    },
    {
      "name": "李娇丽"
    },
    {
      "name": "朱敏"
    },
    {
      "name": "王青娟"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/70tckjyyw813p.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.013",
  "id": "70tckjyyw813p",
  "issns": [
    "1007-4287"
  ],
  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.013",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/70tckjyyw813p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:42Z",
      "native_id": "2655477ecbb244ee924f736b34842128",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.013"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "青少年抑郁患者血清NfL，IGF-1，Netrin-1检测在认知功能诊断中的临床价值",
  "title_text": "青少年抑郁患者血清NfL，IGF-1，Netrin-1检测在认知功能诊断中的临床价值",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:42Z",
  "url": "https://research.draconitic.com/paper/70tckjyyw813p",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}