{
  "abstract": "Understanding how macroscale functional network connectivity (FNC) across the lifespan and in psychopathology is spatially organized with respect to microscale neurobiological architecture remains a challenge. Here, we constructed a cross-omics mapping framework by linking resting-state fMRI data (5,349 individuals, 6-80 years) with 49 neurobiological markers (24 cell types, 19 neurotransmitters, 6 mitochondria). We show that FNC development and aging unfold along cellular and molecular gradients. Specifically, spatial correspondence between age-related FNC changes and neurobiological microprofile networks varied by life stage, peaking for cell types in adolescence, neurotransmitter systems in mid-young adulthood and mitochondrial phenotypes in early adulthood. Applying normative modeling to 5 psychiatric disorders (schizophrenia, bipolar disorder, major depressive disorder, autism, and attention-deficit/hyperactivity disorder), we identified disorder-specific and cross-disorder FNC phenotypes spatially associated with neurobiological architecture. Together, these findings provide a hypothesis-generating framework linking functional brain organization and dysfunction to canonical neurobiological architecture across the lifespan and psychiatric disorders.",
  "abstract_shown": true,
  "affiliations": [
    "Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Em"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "G. Feng"
    },
    {
      "name": "J. Chen"
    },
    {
      "name": "A. Iraji"
    },
    {
      "name": "M. S. E. Sendi"
    },
    {
      "name": "Z. Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "V. D. Calhoun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/713jt7rsye4y3.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.22.761188",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.22.761188v1.full",
  "id": "713jt7rsye4y3",
  "issns": [
    "2692-8205"
  ],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.22.761188v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2805|Functional Brain Connectivity Studies"
    ]
  ],
  "openalex": "W7223683717",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.22.761188v1.full.pdf",
  "pmcid": "PMC13733687",
  "pmid": "42990134",
  "published": "2026-10-22",
  "publisher": "Cold Spring Harbor Laboratory Preprints",
  "ris": "https://research.draconitic.com/paper/713jt7rsye4y3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:29:39Z",
      "native_id": "10.64898/2026.10.22.761188",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.22.761188v1"
    },
    {
      "first_seen": "2026-11-08T12:23:24Z",
      "native_id": "PMC13733687",
      "source": "pmc",
      "url": "https://doi.org/10.64898/2026.10.22.761188"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "From micro-architecture to networks: canonical neurobiological architecture of functional brain organization across the lifespan and in psychopathology",
  "title_text": "From micro-architecture to networks: canonical neurobiological architecture of functional brain organization across the lifespan and in psychopathology",
  "type": "preprint",
  "updated_at": "2026-11-08T12:23:24Z",
  "url": "https://research.draconitic.com/paper/713jt7rsye4y3",
  "venue": "bioRxiv",
  "versions": []
}