{
  "abstract": "Brain computation depends on intricately connected yet highly distributed neural networks. Owing to the absence of the requisite technologies, causally testing fundamental hypotheses on inter-areal processing has remained largely out of reach. Here, we developed a two-photon holographic mesoscope capable of simultaneously reading and writing neural activity patterns with near-single-cell resolution across large regions of the mouse cortex. We demonstrate the precise photoactivation of spatial and temporal sequences of neurons in one or multiple cortical areas while reading out the downstream effects in several other regions. Thus, we have established mesoscale two-photon holographic optogenetics as a platform for mapping functional connectivity and causal interactions across distributed cortical areas with high resolution.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. lamiae.abdeladim@gmail.com",
    "Department of Neuroscience, University of California, Berkeley, CA, USA. lamiae.abdeladim@gmail.com",
    "Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA",
    "Department of Neuroscience, University of California, Berkeley, CA, USA",
    "School of Biological Sciences, Seoul National University, Seoul, Republic of Korea",
    "Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. hadesnik@berkeley.edu",
    "Department of Neuroscience, University of California, Berkeley, CA, USA. hadesnik@berkeley.edu",
    "The Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA. hadesnik@berkeley.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lamiae Abdeladim",
      "orcid": "0000-0002-5015-8653"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Uday K. Jagadisan",
      "orcid": "0000-0003-4253-6041"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Hyeyoung Shin",
      "orcid": "0000-0002-7587-8577"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Mora Belén Ogando",
      "orcid": "0000-0002-1453-2628"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Hillel Adesnik",
      "orcid": "0000-0002-3796-8643"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/71ef5ze03kx48.bib",
  "cited_by": 14,
  "doi": "10.1038/s41593-026-02350-9",
  "fulltext_url": null,
  "id": "71ef5ze03kx48",
  "issns": [
    "1097-6256",
    "1546-1726"
  ],
  "landing_url": "https://doi.org/10.1038/s41593-026-02350-9",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1304|Advanced Fluorescence Microscopy Techniques"
    ]
  ],
  "openalex": "W7172284961",
  "pdf_url": null,
  "pmcid": "PMC10120651",
  "pmid": "37090604",
  "published": "2026-08-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/71ef5ze03kx48.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T13:20:46Z",
      "native_id": "W7172284961",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41593-026-02350-9"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1304|Advanced Fluorescence Microscopy Techniques",
      "subfield": "biophysics"
    }
  ],
  "title": "Probing inter-areal computations with a two-photon holographic mesoscope",
  "title_text": "Probing inter-areal computations with a two-photon holographic mesoscope",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:05Z",
  "url": "https://research.draconitic.com/paper/71ef5ze03kx48",
  "venue": "Nature Neuroscience",
  "versions": []
}